DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and slc22a21

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001295487.1	Gene:	slc22a21 / 799908	ZFINID:	ZDB-GENE-091118-62	Length:	546	Species:	Danio rerio

Alignment Length:	541	Identity:	155/541 - (28%)
Similarity:	247/541 - (45%)	Gaps:	37/541 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KQLEVVGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTHAQKREIV 90
            :|...:|:.|.|...:|.|.....|.|||...|...||..|... |.|||  ..|.|...:...|
Zfish     8 EQTAFLGAWGPFQKTVFSLLCLSIIPNGFTGLSIVFLGDTPAHH-CRIPE--TLNLTAGWRNASV 69

  Fly    91 AKGLDSGGCTVWDWNYGHLAKMSYEAALNYT-GHLTQISPPAEVSCRVKGQHEFAHP-------- 146
            .:....|     |.......::..:...||: |.|.   |..:|:.....:.|.|..
Zfish    70 PRPQPHG-----DPRASRCYRLRLDLVKNYSDGGLL---PGLDVNVSEIPREECADGWIYDKEIY 126

  Fly   147 ETTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTF 211
            .:|.|::|||.|....:..........|...||...|.::|:||||....:..|...:.:....|
Zfish   127 SSTIVSEWDLVCSDDWKSPLTSSIFFCGVLTGSVISGPVSDRFGRKIVLFVTMAIQTLFTVVQVF 191

  Fly   212 SPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRS-WMSIAFSASYPVGMIILAIVGYVIQ 275
            ||.:.:|....|.:|......:..||.:.:|.:....|. :.::.....:.:|.:||.:..:.::
Zfish   192 SPSWQIFCFLFFIVGMGQISNYVAAFVLGMEILSSSVRDVYSTLGVCLFFSIGYMILPLAAFFLR 256

  Fly   276 PWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVASD 340
            .||.|.||||||....|...:.:.||||||::..|......|: |:.:...   .|.||..:...
Zfish   257 DWRSLMLALTIPGFFYIPLWWFIPESPRWLLSQGRVQEAEAII-RKAAKIN---RVTAPDVIFPL 317

  Fly   341 KKSLEPEEGF-SFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAANLSVS 404
            .:|.|...|. ||          |:.||..:|.:|.|......::...|:.|...:||.::|..:
Zfish   318 MQSTEDAGGVQSF----------SVCELLKSSNIRYMTGLLCLIWMAVSIGYCALSLNTSSLHGN 372

  Fly   405 RYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWIVAFAMLGR 469
            .||..:.:.:|::|:.|:..:|||...||..........|:.|||:|.:|...::..:|..|||:
Zfish   373 IYLNCLLSAVVEVPALLMAWLMLRLAPRRHCLASTLALGGLVLLLILLIPEDQSSVTLALVMLGK 437

  Fly   470 FGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGCCVL 534
            ||:||.:|::...|||||||.:||:|||.||..:.||.||||| .:.||:....:|..:.|...:
Zfish   438 FGLSAAFSIIYPVTAELYPTVLRNTALGACSMSSRVGGISAPY-FNYLGSYHRSLPYILIGGINV 501

  Fly   535 VAGLLTLTLPETGTGKLSDKV 555
            ::|||:..|||:....|.:.:
Zfish   502 LSGLLSFLLPESRGSALPETI 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	114/378 (30%)
slc22a21	NP_001295487.1	2A0119	14..521	CDD:273328	154/532 (29%)
slc22a21	NP_001295487.1	MFS	146..511	CDD:119392	114/379 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010