DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and SLC22A5

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001295051.1	Gene:	SLC22A5 / 6584	HGNCID:	10969	Length:	581	Species:	Homo sapiens

Alignment Length:	567	Identity:	157/567 - (27%)
Similarity:	253/567 - (44%)	Gaps:	72/567 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTHAQKREIVAKGLD 95
            :|..|.|...||||.....|.|||...|...|...|:.: |.:|:.  .|.:.|.:...|...|.
Human    11 LGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHR-CRVPDA--ANLSSAWRNHTVPLRLR 72

  Fly    96 SGGCTVWDWNYGHLAKMSYEAALNY-------TGHLTQ--------ISPPAEVSCRVKGQHEFAH 145
            .|...........||.::..:||..       .|.|.|        .|....:|..|..|...|:
Human    73 DGREVPHSCRRYRLATIANFSALGLEPGRDVDLGQLEQESCLDGWEFSQDVYLSTIVTEQDSGAY 137

  Fly   146 ----------PETTFVADWDLTCDRSIQRTSAQVSISL---GKFCGSFSFGILADKFGRKSSFTL 197
                      |.....|.|:|.|:   ....|.::|||   |...|||..|.|:|:||||:
Human   138 NAMKNRMGKKPALCLPAQWNLVCE---DDWKAPLTISLFFVGVLLGSFISGQLSDRFGRKN---- 195

  Fly   198 GAAFFIVG-----SFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFS 257
             ..|..:|     ||...||..:.:|:.....:|......:..||.:..|.:....|    |.||
Human   196 -VLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGKSVR----IIFS 255

  Fly   258 A-----SYPVGMIILAIVGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKI 317
            .     .|..|.::|.:..|.|:.||.|.:|||:|.:|.:...:.:.|||||||:..|::.. ::
Human   256 TLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEA-EV 319

  Fly   318 LFRQPSHYQIQPAVAAPSQVASDKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYF 382
            :.|:.:...   .:..||.:      .:|.|......|.:..  .:|::|.....:|.:...|..
Human   320 IIRKAAKAN---GIVVPSTI------FDPSELQDLSSKKQQS--HNILDLLRTWNIRMVTIMSIM 373

  Fly   383 MFCVTSLSYYVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRR---LTTMFLFLWTG 444
            ::...|:.|:..:|:..||....::....:.:|::|:|::..::|::..||   .|.:||   .|
Human   374 LWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFL---GG 435

  Fly   445 VSLLLVLAVPAGSTTWIVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSIS 509
            ..||.:..||...........|:|:||::|.:|:|.:||||||||.:||..:|..||.:.:|||.
Human   436 SVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSIL 500

  Fly   510 APYVVDVLGALGWYIPTTICGCCVLVAGLLTLTLPETGTGKLSDKVE 556
            :||.| .|||...::|..:.|...::..:|||.|||:....|.|.::
Human   501 SPYFV-YLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTID 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	114/392 (29%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	156/562 (28%)
SLC22A5	NP_001295051.1	MFS	162..534	CDD:119392	114/396 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153680
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940