Protein Alignment CG6356 and Sv2a

DIOPT Version :10

• Sequence 1: NP_651240.1
• Gene: CG6356 / 42893
• FlyBaseID: FBgn0039178
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: NP_071313.1
• Gene: Sv2a / 64051
• MGIID: 1927139
• Length: 742
• Species: Mus musculus
• Alignment Length: 690
• Identity: 144/690 - (20%)
• Similarity: 224/690 - (32%)
• Gaps: 233/690 - (33%)

  Fly    57 SSYTLLGHLPDD-----QWCGIPELQDTNWTHAQKREIVAKGLD----SGGCTVWDWNYG----- 107
            ||....||..||     ::.|||..:.     ..|.|.:|.|..    .||.:..:...|
Mouse    80 SSDATEGHDEDDEIYEGEYQGIPRAES-----GGKGERMADGAPLAGVRGGLSDGEGPPGGRGEA 139

  Fly   108 -------HLAKMSYEAALNYTGH------------LTQISPPAEVSCRVKGQHEFAHPETTFVAD 153
                   .||: .||..|...||            |..::...||.  |.|   |..|.    |:
Mouse   140 QRRKDREELAQ-QYETILRECGHGRFQWTLYFVLGLALMADGVEVF--VVG---FVLPS----AE 194

  Fly   154 WDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTFSPWYSLF 218
            .|: |.....:....:.:.||...|:|.:|.|||:.||:....:..:...|.:||.:|...|..|
Mouse   195 KDM-CLSDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTF 258

  Fly   219 LAGRFALGAASSGLFYPAFTMIVENICL----KHRSWMSIAFSASYPVGMIILAIVGYVIQP--- 276
            |..|...|....|.....|:...|.:..    :|.||:.:    .:.:|.:..|.:.:.|.|
Mouse   259 LFCRLLSGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCM----FWMIGGVYAAAMAWAIIPHYG 319

  Fly   277 -------------WRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKIL-------FRQ 321
                         ||...|....||:..|.......||||:.:.|.::|..:.:|       .|.
Mouse   320 WSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRA 384

  Fly   322 PSH-------------------YQIQP------------AVAAPSQVASDKKS-LEPE------- 347
            ..|                   .:||.            |::...||..:..| ..||
Mouse   385 KGHPERVFSVTHIKTIHQEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITLM 449

  Fly   348 -------EGFSF---------------------------GQKLKNGPLKSIIE-------LYANS 371
                   ..||:                           |:::::......:|       .|.|.
Mouse   450 MMGVWFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFND 514

  Fly   372 K-----VRRMIFA-SYFMFC----VTSLSYY---VTALNAA--NLSVSRY--------------- 406
            |     ::.:.|. |.|..|    |||.:.:   .|.:|..  |..:..|
Mouse   515 KFIGLRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHN 579

  Fly   407 -----LYIIGTG--------------LVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLL---- 448
                 |.:.|||              |..:|..:|..:::...||      |.:..|.|:|
Mouse   580 KEGCPLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGR------LRMLAGSSVLSCVS 638

  Fly   449 -LVLAVPAGSTTWIVAFAMLGRFGIS-ATYSVVTLYTAELYPTQIRNSALG----TCSTFAHVG- 506
             ..|:.....:..|....:.|  |:| |:::.:.:.|.||||:..|.:|.|    .|...|.:|
Mouse   639 CFFLSFGNSESAMIALLCLFG--GVSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGI 701

  Fly   507 SISAPYVVDVLGALGWYIPTTICGCCVLVAGLLTLTLPET 546
            ||...:|.....|     |.......:.:...|.|.||||
Mouse   702 SIFTSFVGITKAA-----PILFASAALALGSSLALKLPET 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS_SLC22	140..544	CDD:340875	112/570 (20%)
Sv2a	NP_071313.1	synapt_SV2	1..742	CDD:130366	144/690 (21%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	40..145		16/69 (23%)