DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and SLC22A11

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_060954.1	Gene:	SLC22A11 / 55867	HGNCID:	18120	Length:	550	Species:	Homo sapiens

Alignment Length:	604	Identity:	140/604 - (23%)
Similarity:	233/604 - (38%)	Gaps:	138/604 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 TKQLEVVGSGGAF----VWAIFFLCV---TPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWT 82
            :|.||..|..|.|    |......|:   :..:|..|   |..:.||.     |         ||
Human     4 SKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENF---SAAIPGHR-----C---------WT 51

  Fly    83 HAQKREIVAKGLDSGGCTVWDWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRV-----KGQHE 142
            |.         ||:|...                       .|.::|.|.::..:     :|.|:
Human    52 HM---------LDNGSAV-----------------------STNMTPKALLTISIPPGPNQGPHQ 84

  Fly   143 ---FAHPE---------------------------------TTFVADWDLTCDRSIQRTSAQVSI 171
               |..|:                                 :|.||.|||.|.....:..:|...
Human    85 CRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIF 149

  Fly   172 SLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTFSPWYSLFLAGRFALGAASSGLFYPA 236
            ..|...|||.:|:|:.:||||...:.......|......|:|.:.::...||......:|:|..:
Human   150 MSGILVGSFIWGLLSYRFGRKPMLSWCCLQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSS 214

  Fly   237 FTMIVENICLKHRSWMSIAFSASYPVGMIILAIVGYVIQPWRHLQLALTIPSLLLILNCYLMSES 301
            .|::||......|:........::..|...|..:.:.::.||.||||.::|...:.|..:.:.||
Human   215 LTLMVEWTTTSRRAVTMTVVGCAFSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPES 279

  Fly   302 PRWLITNQRYDRVYKIL--------FRQPSHYQIQPAVAA-PSQVASDKKSLEPEEGFSFGQKLK 357
            .||||...:.|:..:.|        .::..:..|:..::: ..:|||.|   ||
Human   280 ARWLIIKGKPDQALQELRKVARINGHKEAKNLTIEVLMSSVKEEVASAK---EP----------- 330

  Fly   358 NGPLKSIIELYANSKVR----RMIFASYFMFCVTSLSYYVTALNAANLSVSRYLYIIGTGLVDIP 418
                :|:::|:....:|    .|:..::.:.    :|||....:..:|....:|.....|.||..
Human   331 ----RSVLDLFCVPVLRWRSCAMLVVNFSLL----ISYYGLVFDLQSLGRDIFLLQALFGAVDFL 387

  Fly   419 SYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWIVAFAMLGR--FGISATYSVVTL 481
            ......::|.|.|||..........|:::|..:.||....|..|.||:||:  ||||.|  .:|:
Human   388 GRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRVVFAVLGKGCFGISLT--CLTI 450

  Fly   482 YTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGCCVLVAGLLTL-TLPE 545
            |.|||:||.:|.:|.|...|...:|::..|.::....||. .:|..:.|...:.:.|:.| .|||
Human   451 YKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALP-LLPPLLYGVISIASSLVVLFFLPE 514

  Fly   546 TGTGKLSDKVESSASSTPT 564
            |....|.|.::...|...|
Human   515 TQGLPLPDTIQDLESQKST 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	98/392 (25%)
SLC22A11	NP_060954.1	Sugar_tr	11..523	CDD:331684	134/585 (23%)
SLC22A11	NP_060954.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..550		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153214
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950