DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and slc22a16

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001020659.1	Gene:	slc22a16 / 557279	ZFINID:	ZDB-GENE-041001-166	Length:	565	Species:	Danio rerio

Alignment Length:	573	Identity:	148/573 - (25%)
Similarity:	258/573 - (45%)	Gaps:	83/573 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EVVGSGGAFVWAIF------FLCVTP-NILNGFHVS-SYTLLGHLPDDQWCGIPELQDTNWTHAQ 85
            :.:..|..::.::|      |||..| ||.:..:.: |:|.|..:               |||.:
Zfish    29 QAISCGIHYLASVFLVETPKFLCNPPLNITDVLYKNLSFTSLADI---------------WTHYK 78

  Fly    86 KRE--IVAKGLDSGGCTVWDWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRVKGQHEFAHPET 148
            ..:  :|.:.....     .|......|.....|:|:....  ....:..||   |...:.|.|.
Zfish    79 TGDGPVVVRTSQGD-----QWELSPCLKALRLDAINFQYEF--FGNKSVESC---GAFVYDHSEV 133

  Fly   149 --TFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRK--------SSFTLGAAFFI 203
              :.|.||||.|:|.......|.:..||...|:..||..||:.||:        ..|..|.....
Zfish   134 EQSIVTDWDLVCEREWLAKLTQPTFMLGVLIGALMFGDAADRIGRRPVLMATSLCQFIFGVTVAF 198

  Fly   204 VGSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPVGMIILA 268
            .|:::        ||:..||.|...|||.....|..:.|...:|.|:|.|:...|::.||::::|
Zfish   199 TGNYY--------LFVVMRFLLATVSSGYLVVVFVYVTEFTGIKVRTWTSMHVHAAFAVGIMVVA 255

  Fly   269 IVGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAA 333
            :|||:::.|...|:.||:.:...:|.|:...|:|.:|:...||....::|........:.|.:..
Zfish   256 LVGYLVRVWWIYQIILTLSTSPFLLYCWKFPETPFYLMAKGRYKEAQELLDTMAYINGLPPTLKV 320

  Fly   334 P--------SQVASDKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLS 390
            .        :.:..:|:::|.|:..            |:::::.:.|:.......:.::.:.||.
Zfish   321 SDLQDGCDRTPLKDNKQAMEVEKRL------------SMLDMFGSLKMAGRSATCWAIWFIGSLG 373

  Fly   391 YYVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPA 455
            |||.:|.:.||..::|:.:...|.|::||||:....:...||:.|.....|..||:.:|::.||.
Zfish   374 YYVFSLGSVNLGGNQYINLFLAGAVEVPSYLIGCFAMDRFGRKKTCAPALLLGGVACMLIIVVPQ 438

  Fly   456 GSTTWIVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAP---YVVDVL 517
            ......:..:|.|:|.|:..:.::.|||.|||||.||:.|:|:.|....|||:.||   |:.|:
Zfish   439 DVEVLAIVLSMTGKFAIAIAFGLIYLYTCELYPTIIRSLAVGSGSMMCRVGSVVAPFCVYLADI- 502

  Fly   518 GALGW-YIPTTICGCCVLVAGLLTLTLPETGTGKLSDKVESSASSTPTEPAEK 569
                | |:|..|.|....:.|:||:.||||....|:..:| .|.:..::|..|
Zfish   503 ----WIYLPQLIVGILAFIIGILTMFLPETLGEPLTSTLE-EAEALGSKPNTK 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	108/396 (27%)
slc22a16	NP_001020659.1	2A0119	13..536	CDD:273328	144/556 (26%)
slc22a16	NP_001020659.1	MFS	158..526	CDD:119392	107/392 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588805
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850