DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and SLC22A15

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_060890.2	Gene:	SLC22A15 / 55356	HGNCID:	20301	Length:	547	Species:	Homo sapiens

Alignment Length:	533	Identity:	149/533 - (27%)
Similarity:	243/533 - (45%)	Gaps:	71/533 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EVVGSGGAFVWAIFFLCVTPNILNGFHVSS----YTLLGHLPDDQWCGIPELQDTNWTHAQKREI 89
            :.||..|.:.   .:||....:|...:|::    ..|:|..|...| .:.||. .|.:|..:
Human     8 QAVGEMGIYQ---MYLCFLLAVLLQLYVATEAILIALVGATPSYHW-DLAELL-PNQSHGNQ--- 64

  Fly    90 VAKGLDSGGCTVWDWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRVKGQHEFAHPETTFVADW 154
             :.|.|.   ...||            .|...|        :|:...|    .|:...|:..::|
Human    65 -SAGEDQ---AFGDW------------LLTANG--------SEIHKHV----HFSSSFTSIASEW 101

  Fly   155 DLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTFSPWYSLFL 219
            .|..:||.:.::|......|.|.|..|||.|:|:||||..:..|.|..|:.:....|||.|..|.
Human   102 FLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFA 166

  Fly   220 AGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSAS---YPVGMIILAIVGYVIQPWRHLQ 281
            ..||.:|..:.|:...||.::  |.|:....| ::|.|..   :.||:...|::||.|:.||.|.
Human   167 VTRFLVGMMNGGMSLVAFVLL--NECVGTAYW-ALAGSIGGLFFAVGIAQYALLGYFIRSWRTLA 228

  Fly   282 LALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVASDKKSLEP 346
            :.:.:...::.|....:.||||||.:..|.....:.|:                .:|...:.|:.
Human   229 ILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALY----------------LIAKRNRKLKC 277

  Fly   347 EEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAANLSVSRYLYIIG 411
            ....:...........|.::|:....:........|::.|.||.||...|:|.:|..|.|..:..
Human   278 TFSLTHPANRSCRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLAL 342

  Fly   412 TGLVDIPSYLVPVIML--RFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWIVA------FAMLG 468
            :||::||||.:.:.::  ::.||:.|........|::.|:|:.:|....|.:.|      .::||
Human   343 SGLIEIPSYPLCIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLG 407

  Fly   469 RFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGCCV 533
            :..|||.:::|.:||:|||||.|||..|||||.|:.||.|.||::.. |..:.|.:|..:.|...
Human   408 KLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPS-LKYVQWSLPFIVFGATG 471

  Fly   534 LVAGLLTLTLPET 546
            |.:|||:|.||||
Human   472 LTSGLLSLLLPET 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	116/387 (30%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	110/377 (29%)
		MFS_1	111..450	CDD:284993	105/357 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153619
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850