DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and CG16727

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_650818.1	Gene:	CG16727 / 42338	FlyBaseID:	FBgn0038719	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	551	Identity:	133/551 - (24%)
Similarity:	220/551 - (39%)	Gaps:	74/551 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LEVVGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTHAQKREIVAK 92
            ||..|:.|.|.:.|..|....|||:..|..|.||:...| :.||...:|....  .|:.|.|.:
  Fly     7 LEKCGNFGRFQFVILILYGYTNILSSLHYFSQTLITFTP-EHWCSHDDLMGLG--AAELRSIYS- 67

  Fly    93 GLDSGGCTVWDWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCR-VKGQHEFAHPETTFVADWDL 156
                        |..|.:.......:|.||      ..:|.||: ...:.|..:...|....|
  Fly    68 ------------NVSHPSCTLLSEVINGTG------VASEESCQDWIFERENGYESLTTELKW-- 112

  Fly   157 TCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTF---SPWYSLF 218
            .||:|.|....|....||...|:.|||.|:|..||..:..:.|.....|.|..:|   .||::.
  Fly   113 VCDKSHQPAVGQSFFFLGSVVGTISFGFLSDHIGRLPAMLMAALSGATGDFITSFVHTLPWFAF- 176

  Fly   219 LAGRFALGAASSGLFYPAFTMIVENICLKHRSW-MSIAFSASYPVGMIILAIVGYVIQPWRHLQL 282
              .||..|.::..::|..:.::.|.:..|.|:: ::|..:..|..|::....:...|..||....
  Fly   177 --SRFVSGLSTDTMYYLMYILVFEYLSPKRRTFGLNIILAVFYCFGLMTSPWIAMWIGNWRRYLW 239

  Fly   283 ALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVASDKKSLEPE 347
            ..::|:|.:::...|:.||.:||:|.::||.                |||...:||........:
  Fly   240 LASLPALGVLIYPLLICESAQWLLTKKKYDE----------------AVACLKKVAKFNGRQVED 288

  Fly   348 EGFS-----FGQKLK-----NGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAANLS 402
            ..|.     :.:|:.     |..:.:.:.::...::||..........:.:|||.|...|...|.
  Fly   289 SVFDEFVKHYREKMNEESKLNKQMDTFLGMFKTPRLRRFTTTLLVKSVIITLSYDVINRNMEGLG 353

  Fly   403 VSRYLYIIGTGLVDIPSYLVPVIMLRFTGRR-------LTTMFLFLWTGVSLLLVLAVPAGSTTW 460
            .|.:.....|..|.:|:....:::....||:       |....:...||  .|:.:..|:.:...
  Fly   354 SSPFKLFSLTSSVYLPAGFTILLLQNKIGRKGMACGALLVGAIITAVTG--FLIAVLDPSENAVL 416

  Fly   461 IVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWY-- 523
            :.....|||||.:.:|.....|.||:.||.:|..|:..........|..|.||:    .|..|
  Fly   417 LALMVGLGRFGTTVSYDAEIQYAAEIIPTSVRGQAVSNIHVVGLASSSLAFYVI----YLAQYYK 477

  Fly   524 -IPTTICGCCVLVAGLLTLTLPETGTGKLSD 553
             :|:......:.:..||.||||||...||.:
  Fly   478 PLPSIFISVLMFLGALLCLTLPETLHKKLPE 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	91/400 (23%)
CG16727	NP_650818.1	2A0119	11..509	CDD:273328	131/547 (24%)
CG16727	NP_650818.1	MFS	125..499	CDD:119392	90/398 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458479
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	5.990