DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and CG17752

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_650817.1	Gene:	CG17752 / 42337	FlyBaseID:	FBgn0038718	Length:	538	Species:	Drosophila melanogaster

Alignment Length:	566	Identity:	116/566 - (20%)
Similarity:	211/566 - (37%)	Gaps:	101/566 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LTKQLEVVGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIP-ELQDTNWTHAQKR 87
            |.:.||..|:.|.:...:..|....||::..|..|.||:...|..: |..| |....|:|.....
  Fly     3 LQRVLEKCGNFGPYQILLLGLYGYTNIVSSLHYFSQTLISFTPSHR-CSAPVEEFSQNFTELLSC 66

  Fly    88 EIVAKGLD-----SGGCTVWDWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRVKGQHEFAHPE 147
            .::...:|     ...|:.||          ::...||....|::
  Fly    67 SVIQYDVDMTSFRDNKCSSWD----------FDKESNYESITTEL-------------------- 101

  Fly   148 TTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTFS 212
                 :|  .||.:.:....|....:|...||..||.|||:.||..:..|.......|.||.:|.
  Fly   102 -----EW--VCDDAYKLAVGQSFFFIGSALGSIFFGYLADRIGRLPACVLSTLTGASGDFFTSFV 159

  Fly   213 PWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSW-MSIAFSASYPVGMIILAIVGYVIQP 276
            ....:|...||..|.:....:...:.::.|.:..:||:: ::|.....|.:|::|...:...:..
  Fly   160 GSLPMFSFTRFISGLSMDTQYVLMYILVFEYLSPQHRTFGLNIILGVFYSIGLMISPWIAIWLGN 224

  Fly   277 WRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDR-------VYKILFRQP---------SHY 325
            ||....|.::|:|.:::....:.||..||:|..::|:       |.|...||.         .||
  Fly   225 WRSYLWAASLPALGMLIFPLFLHESVEWLLTKGKFDKAVNNLKSVAKFNGRQVEDSVFDEFIKHY 289

  Fly   326 QIQPAVAAPSQVASDKKSLEPEEGFSFGQKLKNGPLKS---IIELYANSKVRRMIFASYFMFCVT 387
            :                           :||.:...||   .:.:....::|:..........:.
  Fly   290 R---------------------------EKLNSAQKKSSDTFMGMLRTPRLRKFTIILLIKSMII 327

  Fly   388 SLSYYVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRR-------LTTMFLFLWTGV 445
            ::::.:.:.|...:.:|.:.....:|.|.:|..|..::.....||:       |...|:...||
  Fly   328 TIAFDILSRNVEGVGISPFKLFSYSGFVVLPGGLSIILFQNKIGRKGMACASLLVGAFITATTG- 391

  Fly   446 SLLLVLAVPAGSTTWIVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISA 510
             .|:....||..:..:.....|.|||....|.....|.||:.||.:|...:.......:..:..:
  Fly   392 -YLVGTLDPANYSVLLGFMVCLARFGAVVAYDAEAQYAAEIIPTSVRGRGVANIHVVGNAFAFFS 455

  Fly   511 PYVVDVLGALGWYIPTTICGCCVLVAGLLTLTLPETGTGKLSDKVE 556
            .|:: .||.....:|:.:....:::...|.||||||...:|...:|
  Fly   456 SYII-YLGTFYKPLPSLLISFLLIIGACLCLTLPETLHKQLPQTLE 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	82/403 (20%)
CG17752	NP_650817.1	2A0119	11..498	CDD:273328	112/554 (20%)
CG17752	NP_650817.1	MFS	116..488	CDD:119392	81/401 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458481
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	86	1.000	Inparanoid score	I1789
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	6	5.990