DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and CG42269

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_648019.2	Gene:	CG42269 / 38689	FlyBaseID:	FBgn0259164	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	144/546 - (26%)
Similarity:	245/546 - (44%)	Gaps:	72/546 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LEVVGSGGAFVWAIFFLCVTP-NILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTHAQKREIVA 91
            |.::|..|.: ..:.|:|:.| :....|...|...|..:|:..||.:|||...:   .:.|..::
  Fly    76 LPLIGEFGRY-QKLLFICMIPFSFFVAFVYFSQIFLTLIPEQHWCHVPELDGLD---VEARLALS 136

  Fly    92 KGLDSG---GCTVWDWNYGHLAKMSYEAALNYTGHLTQ---ISPP--AEVSCRVKGQHEFAH-PE 147
            ..:.:|   .|.::|              :|||..|.|   ::.|  .:|.||....:.|.. |.
  Fly   137 IPMTNGEYNNCYMYD--------------VNYTDILAQGKVMADPKWPQVKCRHGWSYNFTEIPY 187

  Fly   148 TTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFT----------LGAAFF 202
            .|...:.:..||.:...|.||....||...|...||.:||:|||..:..          :|.||
  Fly   188 ATVATEQNWVCDDAALPTYAQSIFFLGAIVGGLLFGWVADRFGRIPALIGTNMMGLLAGVGTAF- 251

  Fly   203 IVGSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSW---MSIAFSASYPVGM 264
             |.:|      |.  |...||.:|.|....|...:.:::|.:..|:|::   ||||.  .:....
  Fly   252 -VSNF------WE--FAIMRFFVGFAFDNCFTMMYILVLEYVGPKYRTFVANMSIAI--FFTGAA 305

  Fly   265 IILAIVGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKIL--FRQPSHYQI 327
            .:|..:.|.:..|:.|.:..:.|.||.|...:::.||.|||::..:.|:...||  ..:.:..|:
  Fly   306 CLLPWIAYFLADWKLLAIVTSAPLLLAIFTPFVVPESARWLVSQGKVDKAVGILKKLEKGNGRQV 370

  Fly   328 QPAVAAPSQVASDK-KSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSY 391
            .|..   .|:.:|. |.::.:|.       :||.. |:::|:.:.::||.......::...||.:
  Fly   371 PPQT---YQIFTDSCKRMQEQEA-------QNGKY-SVLDLFKSPRLRRTTLLLIVIWMAISLVF 424

  Fly   392 YVTALNAANLSVSRYLYIIGTGLVDIPS-YLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPA 455
            .....|..:|.:..:.........::|: .|:.||:.|| |||.......:.:||..||...||.
  Fly   425 DGHVRNVGSLGLDIFFTFTLACFTELPADTLLTVILDRF-GRRWLACSSMVLSGVFSLLATVVPV 488

  Fly   456 GSTTWIVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGAL 520
            |  .:..|.|::|||.::.:|::...:.||:.||.:|..|:.......:|.||.||:|| .|..:
  Fly   489 G--IYSAALAIMGRFFVNISYNIGLQWAAEVLPTVVRAQAVAFIHIMGYVASIIAPFVV-YLANI 550

  Fly   521 GWYIPTTICGCCVLVAGLLTLTLPET 546
            ...:|..|.|...::.|||.|.||||
  Fly   551 SQALPLIILGILGIIGGLLALLLPET 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	106/393 (27%)
CG42269	NP_648019.2	2A0119	80..552	CDD:273328	132/516 (26%)
CG42269	NP_648019.2	MFS	206..545	CDD:119392	96/364 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45458483
Domainoid	1	1.000	100	1.000	Domainoid score	I351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	97	1.000	Inparanoid score	I321
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
	7	6.990