DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and Slc22a14

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001101663.2	Gene:	Slc22a14 / 316061	RGDID:	1306470	Length:	630	Species:	Rattus norvegicus

Alignment Length:	613	Identity:	146/613 - (23%)
Similarity:	250/613 - (40%)	Gaps:	120/613 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TENPEKNRELISEESMK---------------DLLTKQLE---------------VVGSGGAFVW 39
            ||....|.|..|::|..               ::|.::|:               .:|..|.|.|
  Rat     2 TEEQNSNTEFGSQDSRDSHRHELSYPSQNWSLEMLLRRLKALDDRRDDKFASVLGAIGEFGTFQW 66

  Fly    40 AIFFLCVTPNILNGFHVSS--YTLLGHLPDDQWCGIPELQDTNW--------THAQKREIVAKGL 94
            .:..|...|:||:.|.:.|  :.|....|   :|      :|:|        |..::..:.....
  Rat    67 RLVALTFIPSILSTFFLLSHHFLLTAQRP---YC------NTSWILQVGPNLTEDEQLNLTVPRA 122

  Fly    95 DSGG---CTVW---DWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRVKGQHEFAHPETTFVAD 153
            .:|.   |.::   .|:...:...    .||||           .:|:....:.|||.. :...:
  Rat   123 PNGSFLTCLMYIPVPWDLDSIVHF----GLNYT-----------ETCKHGWIYPFAHTR-SLTNE 171

  Fly   154 WDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTFSPWYSLF 218
            :||.|.......:.|.....|...||..||.|:||.||.....|.....::..|...|...:..:
  Rat   172 FDLVCGNEPHEENGQTVFLSGILTGSLLFGFLSDKLGRYPIILLSLLGILIFGFGTAFVNSFYQY 236

  Fly   219 LAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPVGMIILAIVGYVIQPWRHLQLA 283
            |..||.:..||.|....:.::::|.:..:||:...|.....:.:|:|:|....|.|..||.|.|.
  Rat   237 LFFRFFVAQASVGYAICSVSLVMEWLVGEHRAQAIILQHCFFTIGVILLTGFAYKINHWRLLFLL 301

  Fly   284 LTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVASDKKSLE--- 345
            ..:|...||.|.:::.||||||:...:.:...|:|           ..||    ..:||::.
  Rat   302 GGVPMFPLICNIWVLQESPRWLMVKGKVEEAKKVL-----------CYAA----EVNKKTIPLNL 351

  Fly   346 ------PEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVT---ALNAANL 401
                  |      |:|.|    .||::.|.|..:.:::.|   |.||.....||:   :|...:.
  Rat   352 LNELQLP------GKKAK----ASILDFYTNQHLFKVVLA---MGCVWFTVSYVSLTLSLKMKDF 403

  Fly   402 SVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLT---TMFLFLWTGVSLLLVLAVPAGSTTWIVA 463
            .:..|...:...:..:|:.|..:::|.:.||:.:   |:.|..:|.:|||.   ||....:..:.
  Rat   404 GLDIYFIQVVPCITAVPARLCCILLLEYFGRKWSLNLTLSLVTFTCLSLLF---VPEELKSTTIL 465

  Fly   464 FAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTI 528
            ..:||.|.::.|.|:..:|||||.||.:|::.||..|.....|:||:   :.:.......:|...
  Rat   466 MLVLGEFSMAGTVSIFFIYTAELLPTILRSTGLGMVSIAWTAGAISS---LAIFKQTKTQLPIFF 527

  Fly   529 CGCCVLVAGLLTLTLPETGTGKLSDKVE 556
            |..|.::|...:..:||||...|.|.:|
  Rat   528 CCLCCILALCFSSLVPETGNQPLRDSIE 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	101/391 (26%)
Slc22a14	NP_001101663.2	MFS	147..527	CDD:421695	109/425 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.110