DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and Slc22a15

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001101177.1	Gene:	Slc22a15 / 310732	RGDID:	1311184	Length:	548	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	157/571 - (27%)
Similarity:	255/571 - (44%)	Gaps:	86/571 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EVVGSGGAFVWAIFFLCVTPNILNGFHVSS----YTLLGHLPDDQWCGIPELQDTNWTHAQKREI 89
            :.||..|.:.   .:||....:|...:|::    ..|:|..|...| .:.||. .|.:|:.:..
  Rat     8 QAVGEMGLYQ---MYLCFLLAVLLQLYVATEAILIALIGATPAYHW-DMAELL-PNQSHSNQSS- 66

  Fly    90 VAKGLDSGGCTVWDWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRVKGQHEFAHPETTFVADW 154
             .||...|     ||            .|...|        :|:...|    .|::..|:..::|
  Rat    67 -GKGQAFG-----DW------------LLTANG--------SEIHKHV----HFSNSFTSIASEW 101

  Fly   155 DLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTFSPWYSLFL 219
            .|..:||.:.::|......|.|.|..|||.|:|:||||..:..|.|..|:.:....|||.|..|.
  Rat   102 FLIANRSYKVSAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFA 166

  Fly   220 AGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSAS---YPVGMIILAIVGYVIQPWRHLQ 281
            ..||.:|..:.|:...||.::  |.|:....| ::|.|..   :.||:...|::||.|:.||.|.
  Rat   167 VTRFLVGMMNGGMSLVAFVLL--NECVGAAYW-ALAGSIGGLFFAVGIAQYALLGYFIRSWRTLA 228

  Fly   282 LALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVASDKKSLEP 346
            :.:.:...::.|....:.||||||.:..|.....:.|:                .:|...:.|:.
  Rat   229 ILVNLQGTVVFLLSLFIPESPRWLYSQGRLSEAEEALY----------------LIAKRNRKLKC 277

  Fly   347 EEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAANLSVSRYLYIIG 411
            ....:...........|.::|:....:........|::.|.||.||...|:|.:|..|.|..:..
  Rat   278 TFSLTHPANRSYRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLAL 342

  Fly   412 TGLVDIPSYLVPVIML--RFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWIVA------FAMLG 468
            :||::||||.:.:.::  |:.||:.|........|::.|:|:.:|....|.:.|      .::||
  Rat   343 SGLIEIPSYPLCIYLINQRWFGRKRTLAAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLG 407

  Fly   469 RFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGCCV 533
            :..|||.:::|.:||:|||||.|||..|||||.|:.||.|.||:|.. |..:.|.:|..:.|...
  Rat   408 KLTISAAFNIVYIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFVPS-LKDVQWSLPFIVFGATG 471

  Fly   534 LVAGLLTLTLPET---------------GTGKLSDKVESSASSTPTEPAEK 569
            |.:|||:|.||||               ...:|.::..|..:..|.:|..|
  Rat   472 LTSGLLSLLLPETLNSPLLETFSDLQMYSYRRLGEEALSLQTLDPPQPLGK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	118/387 (30%)
Slc22a15	NP_001101177.1	MFS	111..469	CDD:119392	112/377 (30%)
Slc22a15	NP_001101177.1	MFS_1	111..450	CDD:284993	106/357 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347221
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850