DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and Slc22a4

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_062661.1	Gene:	Slc22a4 / 30805	MGIID:	1353479	Length:	553	Species:	Mus musculus

Alignment Length:	533	Identity:	151/533 - (28%)
Similarity:	247/533 - (46%)	Gaps:	28/533 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTHAQKREIVAKGLD 95
            :|..|.|...||||.....|.|||:..|...|...|:.: |.:|:  ..|.:.:.:...:.....
Mouse    11 LGEWGPFQRLIFFLLSASIIPNGFNGMSVVFLAGTPEHR-CLVPD--TVNLSSSWRNHSIPLETK 72

  Fly    96 SGGCTVWDWNYGHLAKMSYEAALNY-TGHLTQISPPAEVSCRVKGQHEFAHPETTFVADWDLTCD 159
            .|...........||.::..:|:.. .|....:....:.||....:::.....:|.|.:|:|.|:
Mouse    73 DGRQVPQSCRRYRLATIANFSAMGLEPGQDVDLEQLEQESCLDGWEYDKDIFLSTIVTEWNLVCE 137

  Fly   160 RSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTFSPWYSLFLAGRFA 224
            ...:.........:|..||||..|.|:|:||||.......|.....||...||..:.:|......
Mouse   138 DDWKTPLTTSLFFVGVLCGSFVSGQLSDRFGRKKVLFATMAVQTGFSFVQIFSTNWEMFTVLFAI 202

  Fly   225 LGAASSGLFYPAFTMIVENICLKHRSWMSIAFS-----ASYPVGMIILAIVGYVIQPWRHLQLAL 284
            :|......:..||.:..|.:....|    |.||     ..:.:|.::|.:..|.|:.||.|.|||
Mouse   203 VGMGQISNYVVAFILGTEILSKSVR----IIFSTLGVCTFFAIGYMVLPLFAYFIRDWRMLLLAL 263

  Fly   285 TIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVASDKKSLEPEEG 349
            |:|.|..:...:.:.|||||||:.:|:....:|:.:...    ..::.||:.:..   .||.:|.
Mouse   264 TLPGLFCVPLWWFIPESPRWLISQRRFAEAEQIIQKAAK----MNSIVAPAGIFD---PLELQEL 321

  Fly   350 FSFGQKLKNGPLKSII-ELYANSKVRRMIFASYFMFCVTSLSYYVTALNAANLSVSRYLYIIGTG 413
            .|..|:      |.|| :|:....:..:...:..::.:||:.|:..:||..||....||....:|
Mouse   322 NSLKQQ------KVIILDLFRTRNIATITVMAVMLWMLTSVGYFALSLNVPNLHGDVYLNCFLSG 380

  Fly   414 LVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWIVAFAMLGRFGISATYSV 478
            |:::|:|....::||...||.....:..|.|..|||:..||.......:...|||:|||::.:|:
Mouse   381 LIEVPAYFTAWLLLRTLPRRYIIAGVLFWGGGVLLLIQVVPEDYNFVSIGLVMLGKFGITSAFSM 445

  Fly   479 VTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGCCVLVAGLLTLTL 543
            :.::|||||||.:||.|:|..|..:.||||.|||.| .|||....:|..:.|...::.|::||..
Mouse   446 LYVFTAELYPTLVRNMAVGITSMASRVGSIIAPYFV-YLGAYNRLLPYILMGSLTVLIGIITLFF 509

  Fly   544 PETGTGKLSDKVE 556
            ||:....|.:.:|
Mouse   510 PESFGVTLPENLE 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	118/382 (31%)
Slc22a4	NP_062661.1	2A0119	12..519	CDD:273328	150/527 (28%)
Slc22a4	NP_062661.1	MFS	123..510	CDD:119392	123/404 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843838
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940