DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and Slc22a22

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001013969.1	Gene:	Slc22a22 / 299944	RGDID:	1304605	Length:	555	Species:	Rattus norvegicus

Alignment Length:	580	Identity:	136/580 - (23%)
Similarity:	231/580 - (39%)	Gaps:	109/580 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LEVVGSGGAF-VWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDT--NWTHAQKREI 89
            |..||..|.| :|.|..|    |||:  .|||                 |.|.  |:|.|
  Rat     7 LHHVGDRGRFQIWMIVVL----NILS--MVSS-----------------LHDVIENFTAA----- 43

  Fly    90 VAKGLDSGGCTVWDWNYGHLAKMSYEAALNYTGH-LTQISPPAEVSCRVKGQHEFAHPE------ 147
                :.:..|:|   |....::.....|:|.|.. :.::|.|...:.:.:....|.||:
  Rat    44 ----IPAHHCSV---NLLDTSRSEISMAMNLTTEAMMKVSIPMGPNQKPEQCRRFRHPQWQFIDS 101

  Fly   148 ---------------------------TTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGIL 185
                                       :|.|.:|||.||....:..||.:...|.|..:...||:
  Rat   102 NISTSNSTELETEPCLDGWTYDHSVFTSTIVTEWDLVCDFQSFKYYAQATSLAGHFVAAPFCGII 166

  Fly   186 ADKFGRKSSFT-LGAAFFIVGSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHR 249
            :|:||||.... ...|:.|:|: .|.|.|.:||:...||...|::|.:......:::|...::..
  Rat   167 SDRFGRKPLLMYCSLAYGILGT-CCAFVPNFSLYCVLRFLSSASASTVGMNCLILVLEETSVQWH 230

  Fly   250 SWMSIAFSASYPVGMIILAIVGYVIQPWRHLQLALTIP-SLLLILNCYLMSESPRWLITNQRYDR 313
            :.:.:........|:..|..:.||:..|..:||...:| .:..||.|: :.||.|||:...:.|:
  Rat   231 ATVIVLSGLFSSTGLAGLGGLAYVLSDWHLIQLTSALPYFIFFILFCW-VPESARWLMITGKTDQ 294

  Fly   314 VYKILFRQPSHYQIQPAVAAPSQVA-----SDKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKV 373
            ..|.|.|..|       :.....:|     .|.:|...|:..|   .:|:..:|.||   .|..:
  Rat   295 ALKELQRIAS-------INGKKDIAQNLTTEDLRSKVKEDVCS---TVKHFSIKDII---INPMI 346

  Fly   374 RRMIFASYFMFCVTSLSYYVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMF 438
            |:::.....:......|.:...|:...|..:.::..|..|::||||..:...:||...||....|
  Rat   347 RKIVLCYSSVLFAELFSIFGLLLDVHMLGKNIFVTQILLGVIDIPSKSLTYFILRNVRRRPLIAF 411

  Fly   439 LFLWTGVSLLLVLAVPAGSTTWIVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFA 503
            |...||..:.:.:.:........:|..:||:...:|..|:.|.|..||.|..:|::..|...:.|
  Rat   412 LLFATGGCITITMFLSEDMYVLRLAIFILGKGCFAAFISINTAYCNELSPVPLRSTLNGIYISVA 476

  Fly   504 HVGS-------ISAPYVVDVLGALGWYIPTTICGCCVLVAGLLTLTLPETGTGKLSDKVE 556
            .:.|       ::..|.|        .:|...||...:||.:....||||....::|.::
  Rat   477 RLASVLSALTLVTRKYFV--------LLPMIFCGVLPIVATINIYFLPETFNHPITDTIK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	94/390 (24%)
Slc22a22	NP_001013969.1	2A0119	11..526	CDD:273328	133/572 (23%)
Slc22a22	NP_001013969.1	MFS	127..516	CDD:119392	101/411 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347272
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950