DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and Slc22a6

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_058920.1	Gene:	Slc22a6 / 29509	RGDID:	69338	Length:	551	Species:	Rattus norvegicus

Alignment Length:	571	Identity:	150/571 - (26%)
Similarity:	240/571 - (42%)	Gaps:	60/571 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SMKDLLTKQLEVVGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTH 83
            :..||| ||   ||..|.|......:.|.|.:|...|.:.......:|... |..|...:.:
  Rat     2 AFNDLL-KQ---VGGVGRFQLIQVTMVVAPLLLMASHNTLQNFTAAIPPHH-CRPPANANLS--- 58

  Fly    84 AQKREIVAKGLDSGGCTVWDWNYGHLAKMSY-EAALNYTGHLTQISPPAEVSCRVKGQH------ 141
                       ..||...|    ..|.|... |:.|.:|.  .|..||........|..
  Rat    59 -----------KDGGLEAW----LPLDKQGQPESCLRFTS--PQWGPPFYNGTEANGTRVTEPCI 106

  Fly   142 -EFAHPETTF----VADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAF 201
             .:.:..:||    |.:|:|.|.....|..||....:|...|:..||.|||:.||:....|....
  Rat   107 DGWVYDNSTFPSTIVTEWNLVCSHRAFRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQ 171

  Fly   202 FIVGSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPVGMII 266
            ..|......::|.|:::...|...|.:.:.:.....|:.||.:.:..|:::.......|.:|..:
  Rat   172 TAVSGTCAAYAPNYTVYCVFRLLSGMSLASIAINCMTLNVEWMPIHTRAYVGTLIGYVYSLGQFL 236

  Fly   267 LAIVGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYD-------RVYKILFRQPSH 324
            ||.:.|.:..||||||.:::|..:..:..:...||.||..::.|.|       ||.:|..:|...
  Rat   237 LAGIAYAVPHWRHLQLVVSVPFFIAFIYSWFFIESARWYSSSGRLDLTLRALQRVARINGKQEEG 301

  Fly   325 YQIQPAVAAPSQVASDKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSL 389
            .::...|.        :.||:.|...|.||       .|.:||.....:|.:......::..||.
  Rat   302 AKLSIEVL--------RTSLQKELTLSKGQ-------ASAMELLRCPTLRHLFLCLSMLWFATSF 351

  Fly   390 SYYVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVP 454
            :||...::.....||.||..:..|.||:|:..|..:::...|||...|...|..|:.:|:...:|
  Rat   352 AYYGLVMDLQGFGVSMYLIQVIFGAVDLPAKFVCFLVINSMGRRPAQMASLLLAGICILVNGIIP 416

  Fly   455 AGSTTWIVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGA 519
            ...|....:.|:||:..::::::.:.|||.|||||.||.:.||..||.|.||||.:| :|.:...
  Rat   417 KSHTIIRTSLAVLGKGCLASSFNCIFLYTGELYPTVIRQTGLGMGSTMARVGSIVSP-LVSMTAE 480

  Fly   520 LGWYIPTTICGCCVLVAGLLTLTLPETGTGKLSDKVESSASSTPTEPAEKQ 570
            ....:|..|.|...:||..:|..||||....|.|.|:...|.:..:..::|
  Rat   481 FYPSMPLFIFGAVPVVASAVTALLPETLGQPLPDTVQDLKSRSRGKQNQQQ 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	106/383 (28%)
Slc22a6	NP_058920.1	2A0119	11..515	CDD:273328	140/540 (26%)
		MFS	135..505	CDD:119392	106/385 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	514..551		4/18 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347271
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950