DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_036829.1	Gene:	Slc22a1 / 24904	RGDID:	3224	Length:	556	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	150/551 - (27%)
Similarity:	245/551 - (44%)	Gaps:	48/551 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EVVGSGGAFVW----AIFFLCVTPNILNGFHVSSYTLLGHLPDDQWC---GIPEL-QDTNWTHAQ 85
            :|:...|.|.|    |...||:....|...:| ....||..| ..:|   |:.|| |...|:.|:
  Rat     6 DVLEQVGEFGWFQKQAFLLLCLISASLAPIYV-GIVFLGFTP-GHYCQNPGVAELSQRCGWSQAE 68

  Fly    86 KREIVAKGLDSGG-------CTVW--DWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRVKGQH 141
            :......||....       |..:  |||...|..:...::|........:.|     |    :|
  Rat    69 ELNYTVPGLGPSDEASFLSQCMRYEVDWNQSTLDCVDPLSSLVANRSQLPLGP-----C----EH 124

  Fly   142 EFAH--PETTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIV 204
            .:.:  |.::.|.:::|.|..:.:....|..::||.|.||...|.:||:||||....:......|
  Rat   125 GWVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSV 189

  Fly   205 GSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPVGMIILAI 269
            .......:|.|:..|..|...|..|.|.:...:|:|.|.:...:|...:|.:..::.||::.||.
  Rat   190 SGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQMAFTVGLVGLAG 254

  Fly   270 VGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFR-QPSHYQIQPAVAA 333
            |.|.|..||.||||:::|:.|.:|..:.:.||||||::.:|..|..:|:.: ...:.::.||
  Rat   255 VAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTRAVRIMEQIAQKNGKVPPA--- 316

  Fly   334 PSQVASDKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNA 398
                  |.|.|..||..|    .|..|  |..:|:....:|:......:::...::.|....::.
  Rat   317 ------DLKMLCLEEDAS----EKRSP--SFADLFRTPNLRKHTVILMYLWFSCAVLYQGLIMHV 369

  Fly   399 ANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWI-V 462
            .....:.||....:.||:.|:..:.::.:...||........|.||.:.||::.:| ....|: |
  Rat   370 GATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVTGAACLLMIFIP-HELHWLNV 433

  Fly   463 AFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTT 527
            ..|.|||.|.:....:|.|..||||||.|||..:..||....:|.|..|::|..|..:...:|..
  Rat   434 TLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEVWQALPLI 498

  Fly   528 ICGCCVLVAGLLTLTLPETGTGKLSDKVESS 558
            :.|...|.||.:||.||||....|.:.:|.:
  Rat   499 LFGVLGLTAGAMTLLLPETKGVALPETIEEA 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	110/378 (29%)
Slc22a1	NP_036829.1	2A0119	12..525	CDD:273328	148/539 (27%)
Slc22a1	NP_036829.1	MFS	125..515	CDD:119392	114/405 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347265
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950