DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG6356 and SV2C

DIOPT Version :9

Sequence 1:NP_651240.1 Gene:CG6356 / 42893 FlyBaseID:FBgn0039178 Length:570 Species:Drosophila melanogaster
Sequence 2:NP_055794.3 Gene:SV2C / 22987 HGNCID:30670 Length:727 Species:Homo sapiens


Alignment Length:696 Identity:139/696 - (19%)
Similarity:224/696 - (32%) Gaps:251/696 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    57 SSYTLLGHLPDD-----QWCGIPELQDTNWTHAQKREIVAKGLDSGGCTVWDWNYGHLAKM---- 112
            ||....||..||     ::.|||.:...      |..||:.|...|.      .|....::    
Human    75 SSEATEGHDEDDEIYEGEYQGIPSMNQA------KDSIVSVGQPKGD------EYKDRRELESER 127

  Fly   113 ---------SYEAALNYTGH------------LTQISPPAEVSCRVKGQHEFAHPETTFVADWDL 156
                     .||..:...||            :..::...||.  |.|   |..|.    |:.||
Human   128 RADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVF--VVG---FVLPS----AETDL 183

  Fly   157 TCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAA---FFIVGSFFCTFSPWYSLF 218
            ....|.......: :.||...|:|.:|.||||.|||.|..:..:   ||   :|..:|...|..|
Human   184 CIPNSGSGWLGSI-VYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFF---AFLSSFVQGYGFF 244

  Fly   219 LAGRFALGAASSGLFYPAFTMIVENICL----KHRSWMSIAFSASYPVGMIILAIVGYVIQP--- 276
            |..|...|....|.....|:...|.:..    :|.||:.:    .:.:|.|..:.:.:.|.|   
Human   245 LFCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCM----FWMIGGIYASAMAWAIIPHYG 305

  Fly   277 -------------WRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKIL-------FR- 320
                         ||...:...:|.:..::....|.||||:|:...::|..:.||       .| 
Human   306 WSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRA 370

  Fly   321 --QPSHYQIQPAVAAPSQVASDKKSLEPEEGF----------------------SFGQKLKNGPL 361
              ||........:..|.|: .:...:|.:.|.                      .|...:::..:
Human   371 RGQPEKVFTVNKIKTPKQI-DELIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRDNTI 434

  Fly   362 KSII-------------------------------------ELYAN------------------- 370
            |..|                                     :.|||                   
Human   435 KLTIVWFTLSFGYYGLSVWFPDVIKPLQSDEYALLTRNVERDKYANFTINFTMENQIHTGMEYDN 499

  Fly   371 -----SKVRRMIFA-SYFMFC----VTSLSYY---VTALNAA--NLSVSRYLYI----------- 409
                 .|.:.:.|. |.|..|    |||::.|   .|.::..  |.....|.:|           
Human   500 GRFIGVKFKSVTFKDSVFKSCTFEDVTSVNTYFKNCTFIDTVFDNTDFEPYKFIDSEFKNCSFFH 564

  Fly   410 -----------------------IGTGLVDIPSYLVPVIMLRFTGRRLT----TMFL------FL 441
                                   :|| |..:|..:|..:::...| |||    :|.|      ||
Human   565 NKTGCQITFDDDYSAYWIYFVNFLGT-LAVLPGNIVSALLMDRIG-RLTMLGGSMVLSGISCFFL 627

  Fly   442 WTGVSLLLVLAVPAGSTTWIVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALG----TCSTF 502
            |.|.|..:::.:          ..:.....||| ::.:.:.|.|||||..|.:..|    .|...
Human   628 WFGTSESMMIGM----------LCLYNGLTISA-WNSLDVVTVELYPTDRRATGFGFLNALCKAA 681

  Fly   503 AHVGSISAPYVVDVLGALGWYIPTTICGCCVLVAGLLTLTLPETGT 548
            |.:|::....:|.:..::...:.:|:..|    .||:.|.||:|.|
Human   682 AVLGNLIFGSLVSITKSIPILLASTVLVC----GGLVGLCLPDTRT 723

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG6356NP_651240.1 MFS 167..544 CDD:119392 106/550 (19%)
SV2CNP_055794.3 synapt_SV2 1..727 CDD:130366 139/696 (20%)
Interaction with SYT1. /evidence=ECO:0000250 1..57
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..84 4/8 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 109..128 3/24 (13%)
MFS 155..719 CDD:119392 116/598 (19%)
Pentapeptide_3 507..561 CDD:290309 12/53 (23%)
(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269|PubMed:27294781 519..563 9/43 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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