DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and Slc22a5

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_035526.1	Gene:	Slc22a5 / 20520	MGIID:	1329012	Length:	557	Species:	Mus musculus

Alignment Length:	533	Identity:	144/533 - (27%)
Similarity:	236/533 - (44%)	Gaps:	28/533 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTHAQKREIVAKGLD 95
            :|..|.|...||||.....|.|||:..|...|...|:.: |.:|  ...|.:.|.:...:.....
Mouse    11 LGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAGTPEHR-CLVP--HTVNLSSAWRNHSIPLETK 72

  Fly    96 SGGCTVWDWNYGHLAKMSYEAALNY-TGHLTQISPPAEVSCRVKGQHEFAHPETTFVADWDLTCD 159
            .|...........||.::..:.|.. .|....:....:.||....:::.....:|.|.:|||.|.
Mouse    73 DGRQVPQKCRRYRLATIANFSELGLEPGRDVDLEQLEQESCLDGWEYDKDVFLSTIVTEWDLVCK 137

  Fly   160 RSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTFSPWYSLFLAGRFA 224
            ...:.........:|...|||..|.|:|:||||:...|........||...||..:.:|......
Mouse   138 DDWKAPLTTSLFFVGVLMGSFISGQLSDRFGRKNVLFLTMGMQTGFSFLQVFSVNFEMFTVLFVL 202

  Fly   225 LGAASSGLFYPAFTMIVENICLKHR-SWMSIAFSASYPVGMIILAIVGYVIQPWRHLQLALTIPS 288
            :|......:..||.:..|.:....| .:.::.....|..|.::|.:..|.|:.||.|.||||:|.
Mouse   203 VGMGQISNYVAAFVLGTEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPG 267

  Fly   289 LLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQV-----ASDKKSLEPEE 348
            :|.....:.:.|||||||:..|.... :::.|:.:...   .:.|||.:     ..|..|.:|:
Mouse   268 VLCGALWWFIPESPRWLISQGRIKEA-EVIIRKAAKIN---GIVAPSTIFDPSELQDLNSTKPQ- 327

  Fly   349 GFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAANLSVSRYLYIIGTG 413
                        |..|.:|.....:|.:...|..::...|:.|:..:|:..||....|:......
Mouse   328 ------------LHHIYDLIRTRNIRVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLA 380

  Fly   414 LVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWIVAFAMLGRFGISATYSV 478
            .|::|:|::..::|::..||.:........|..||.:..||:.......|..|:|:|||::.||:
Mouse   381 AVEVPAYVLAWLLLQYLPRRYSISAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSM 445

  Fly   479 VTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGCCVLVAGLLTLTL 543
            |.:||||||||.:||..:|..||.:.:|||.:||.| .|||...::|..:.|...::..:|||..
Mouse   446 VYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV-YLGAYDRFLPYILMGSLTILTAILTLFF 509

  Fly   544 PETGTGKLSDKVE 556
            ||:....|.|.::
Mouse   510 PESFGVPLPDTID 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	109/382 (29%)
Slc22a5	NP_035526.1	2A0119	12..520	CDD:273328	143/528 (27%)
Slc22a5	NP_035526.1	MFS	123..510	CDD:119392	115/404 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843839
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940