DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and Slc22a2

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_038695.1	Gene:	Slc22a2 / 20518	MGIID:	1335072	Length:	553	Species:	Mus musculus

Alignment Length:	563	Identity:	155/563 - (27%)
Similarity:	250/563 - (44%)	Gaps:	48/563 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LEVVGSGGAFVWAIFFLCVTPNILNGFHVSSY---TLLGHLPDDQWC---GIPEL-QDTNWTHAQ 85
            ||.:|....|....|||..   :|:|.....|   ..||..|:.. |   |:.|| |...|:.|:
Mouse     8 LEHIGEFHLFQKQTFFLLA---LLSGAFTPIYVGIVFLGFTPNHH-CRSPGVAELSQRCGWSPAE 68

  Fly    86 KREIVAKGLDSGG-------CTVW--DWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRVKGQH 141
            :......||.|.|       |..:  |||...|..:...::|........:||     |    :|
Mouse    69 ELNYTVPGLGSAGEVSFLSQCMRYEVDWNQSTLDCVDPLSSLAANRSHLPLSP-----C----EH 124

  Fly   142 EFAH--PETTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIV 204
            .:.:  |.::.|.:::|.|..|......|..:::|.|.|:...|.|||:||||....:......:
Mouse   125 GWVYDTPGSSIVTEFNLVCAHSWMLDLFQSLVNVGFFIGAVGIGYLADRFGRKFCLLVTILINAI 189

  Fly   205 GSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPVGMIILAI 269
            .......||.|:..|..||..|..|...:...:.:|.|.:.|.:|..:.|.:..::.||::|||.
Mouse   190 SGVLMAISPNYAWMLVFRFLQGLVSKAGWLIGYILITEFVGLGYRRTVGICYQIAFTVGLLILAG 254

  Fly   270 VGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAP 334
            |.|.:..||.||.|:|:|:...:|..:.:.|||||||:..:..:..||:    .|...:...:.|
Mouse   255 VAYALPNWRWLQFAVTLPNFCFLLYFWCIPESPRWLISQNKNAKAMKII----KHIAKKNGKSVP 315

  Fly   335 SQVASDKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAA 399
            ..:    :||..:|  ..|.||.    .|.::|....::|:......:.:..:|:.|....::..
Mouse   316 VSL----QSLTADE--DTGMKLN----PSFLDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMG 370

  Fly   400 NLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWI-VA 463
            ....:.||....:.||:.|:..:.::.:...|||.......:..|.:.|..:.:| ....|: :.
Mouse   371 LAGDNIYLDFFYSALVEFPAAFIIILTIDRIGRRYPWAVSNMVAGAACLASVFIP-DDLQWLKIT 434

  Fly   464 FAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTI 528
            .|.|||.||:..|.:|.|..||||||.|||.|:..||:...:|.|..|::|..|..:....|..:
Mouse   435 VACLGRMGITIAYEMVCLVNAELYPTYIRNLAVLVCSSMCDIGGIVTPFLVYRLTDIWLEFPLVV 499

  Fly   529 CGCCVLVAGLLTLTLPETGTGKLSDKVESSAS-STPTEPAEKQ 570
            .....||||.|.|.||||....|.:.:|.:.. ..|.:..||:
Mouse   500 FAVVGLVAGGLVLLLPETKGKALPETIEDAEKMQRPRKKKEKR 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	107/377 (28%)
Slc22a2	NP_038695.1	2A0119	12..525	CDD:273328	149/540 (28%)
Slc22a2	NP_038695.1	MFS	125..492	CDD:119392	105/381 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843824
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950