DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and Slc22a1

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_033228.2	Gene:	Slc22a1 / 20517	MGIID:	108111	Length:	556	Species:	Mus musculus

Alignment Length:	558	Identity:	148/558 - (26%)
Similarity:	244/558 - (43%)	Gaps:	62/558 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EVVGSGGAFVW----AIFFLCVTPNILNGFHVSSYTLLGHLPDDQWC---GIPEL-QDTNWTHAQ 85
            :|:...|.|.|    |...||:....|...:| ....||..||.. |   |:.|| |...|:.|:
Mouse     6 DVLEHVGEFGWFQKQAFLLLCLISASLAPIYV-GIVFLGFTPDHH-CRSPGVAELSQRCGWSPAE 68

  Fly    86 KREIVAKGLDSGG-------CTVW--DWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRVKGQH 141
            :......||.|.|       |..:  |||...|..:...::|........:||     |    :|
Mouse    69 ELNYTVPGLGSAGEASFLSQCMKYEVDWNQSTLDCVDPLSSLAANRSHLPLSP-----C----EH 124

  Fly   142 EFAH--PETTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIV 204
            .:.:  |.::.|.:::|.|..:.:....|..::||.|.||...|.:||:||||....:......:
Mouse   125 GWVYDTPGSSIVTEFNLVCGDAWKVDLFQSCVNLGFFLGSLVVGYIADRFGRKLCLLVTTLVTSL 189

  Fly   205 GSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPVGMIILAI 269
            .......:|.|:..|..|...|..|.|.:...:|:|.|.:...:|...:|.:..::.||::.||.
Mouse   190 SGVLTAVAPDYTSMLLFRLLQGMVSKGSWVSGYTLITEFVGSGYRRTTAILYQVAFTVGLVGLAG 254

  Fly   270 VGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAP 334
            |.|.|..||.||||:::|:.|.:|..:.:.||||||::.:|..:..:|:
Mouse   255 VAYAIPDWRWLQLAVSLPTFLFLLYYWFVPESPRWLLSQKRTTQAVRIM---------------- 303

  Fly   335 SQVASDKKSLEP--------EEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSY 391
            .|:|...:.:.|        ||..|    .:..|  |..:|:....:|:......:::...::.|
Mouse   304 EQIAQKNRKVPPADLKMMCLEEDAS----ERRSP--SFADLFRTPSLRKHTLILMYLWFSCAVLY 362

  Fly   392 YVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAG 456
            ....::......:.||....:.||:.|:..:.::.:...||........|..|.:.||::.:| .
Mouse   363 QGLIMHVGATGANLYLDFFYSSLVEFPAAFIILVTIDRIGRIYPIAASNLVAGAACLLMIFIP-H 426

  Fly   457 STTWI-VAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGAL 520
            ...|: |..|.|||.|.:....:|.|..||||||.|||..:..||....:|.|..|::|..|..:
Mouse   427 ELHWLNVTLACLGRMGATIVLQMVCLVNAELYPTFIRNLGMMVCSALCDLGGIFTPFMVFRLMEV 491

  Fly   521 GWYIPTTICGCCVLVAGLLTLTLPETGTGKLSDKVESS 558
            ...:|..:.|...|.||.:||.||||....|.:.:|.:
Mouse   492 WQALPLILFGVLGLSAGAVTLLLPETKGVALPETIEEA 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	104/385 (27%)
Slc22a1	NP_033228.2	2A0119	12..525	CDD:273328	146/546 (27%)
Slc22a1	NP_033228.2	MFS	125..515	CDD:119392	108/412 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843841
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.950