DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	565	Identity:	150/565 - (26%)
Similarity:	238/565 - (42%)	Gaps:	69/565 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 LEVVGSGGAFVWAIFFLCVTP-------NILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTHAQ 85
            |:.|||.|.|.:....|...|       |:|..|..::        .|..|..|
Mouse     7 LDRVGSMGPFQYLHVTLLALPILGIANHNLLQIFTATT--------PDHHCRPP----------- 52

  Fly    86 KREIVAKGLDSGGCTVWDWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRVKGQHE-------F 143
                     .:.....|....|...|.  |..|.:. ||...|.|.:    .:|..|       :
Mouse    53 ---------PNASLEPWVLPLGPNGKP--EKCLRFV-HLPNASLPND----TQGATEPCLDGWIY 101

  Fly   144 AHPETTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFF 208
            .....|.|.:|||.|..:..:..||.....|...|...||.|:|:||||...|............
Mouse   102 NSTRDTIVTEWDLVCGSNKLKEMAQSVFMAGILVGGPVFGELSDRFGRKPILTWSYLLLAASGSS 166

  Fly   209 CTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPVGMIILAIVGYV 273
            ..|||..::::..||..|.:.||:......:.||.:....|:..|......|.:|..||..:.|.
Mouse   167 AAFSPSLTVYMIFRFLCGCSISGISLSTIILNVEWVPTSTRAISSTTIGYCYTIGQFILPGLAYA 231

  Fly   274 IQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVA 338
            :..||.|||:::....:..|..:.:.||.|||:.:.::.:..|.|.|          ||..:...
Mouse   232 VPQWRWLQLSVSAAFFIFSLLSWWVPESIRWLVLSGKFSKALKTLQR----------VATFNGKK 286

  Fly   339 SDKKSLEPEE-GFSFGQKLKNGPLK-SIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAANL 401
            .:.:.|..|| .|:..:.:.:..:| .:.:|:..|.:||:.|.....:..|..:||..|:.....
Mouse   287 EEGEKLTVEELKFNLQKDITSAKVKYGLSDLFRVSILRRVTFCLSLAWFATGFAYYSLAMGVEEF 351

  Fly   402 SVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWIVAFAM 466
            .|:.|:..|..|.||||:..:.::.:.:.|||:|..||.:..||::|.::.|.:.......|.|:
Mouse   352 GVNIYILQIIFGGVDIPAKFITILSISYLGRRITQGFLLILAGVAILALIFVSSEMQLLRTALAV 416

  Fly   467 LGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGC 531
            .|:..:|.::|.:.|||:|||||.:|.:.:|..:.:|.|||:.|| :|.:.|.|..:||..|.|.
Mouse   417 FGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNIWARVGSMIAP-LVKITGELQPFIPNVIFGT 480

  Fly   532 CVLVAGLLTLTLPETGTGKLSDKVE------SSASSTPTEP-AEK 569
            ..|:.|.....|.||....|.:.:|      .....|..|| |||
Mouse   481 MTLLGGSAAFFLLETLNRPLPETIEDIQDWYQQTKKTKQEPEAEK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	108/378 (29%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	141/537 (26%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537		6/13 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843849
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950