DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and Slc22a27

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_017173565.1	Gene:	Slc22a27 / 171405	MGIID:	3042283	Length:	576	Species:	Mus musculus

Alignment Length:	566	Identity:	137/566 - (24%)
Similarity:	238/566 - (42%)	Gaps:	74/566 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SMKDLLTKQLEVVGSGGAF-VWAIFFLCVTPNILNGF---HVSSYTLLGHLPDDQWCGIPELQDT 79
            |.::||.:    |||.|.| :..|.||.    :||..   |::.......:|:.: |.:|.|.:.
Mouse    27 SFQELLNQ----VGSLGRFQILQIVFLL----LLNAIVVPHIAMENFTAAIPNHR-CWVPILDND 82

  Fly    80 NWTHAQKREI-------VAKGLDSG----GCTVWDWNYGHLAKMSYEAALNYTGHLTQISPPAEV 133
            ..:....|.:       ::..|||.    .|..:.....||        |:..|..:.:|.|...
Mouse    83 TASDNGSRILSQDDLLRISIPLDSNLRPEKCRRFAQPQWHL--------LHLNGTFSNVSEPDTE 139

  Fly   134 SCRVKGQHEFAHPETTFVADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLG 198
            .|.....::.::..:|.|.:|||.|:.....:..:.|..:|.|.|....|.|:|:.|||...|..
Mouse   140 PCVDGWVYDRSNFLSTIVTEWDLVCESQALNSVTKFSFMIGLFIGGIICGHLSDRLGRKFILTCA 204

  Fly   199 AAFFIVGSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPVG 263
            ...|.:......|:|.:.::.:.||..|.:...:...:..:::|....|..:.|:...|.:..:|
Mouse   205 LLQFAITETCVAFAPSFFIYCSLRFLAGLSVEPILVNSHLLMLEWTSPKFLTMMAALLSCAPNIG 269

  Fly   264 MIILAIVGYVIQPWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQ-- 326
            .:|.|.:.::.:.|.||||.:::|....::....:|||.||||...:..:..|.| |:.:|..
Mouse   270 YMISAGLAFLFRIWHHLQLTMSVPIFFFLILTRWLSESARWLIVTNKPQKGLKEL-RKVAHMNGM 333

  Fly   327 ----------IQPAVAAPSQVASDKKSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASY 381
                      ::.::.|..:.|..|.||.                    :|:..|.:|:.|....
Mouse   334 KNSGDLTMEIVRTSMKAELEAAKTKPSLR--------------------DLFHTSILRKRICVLS 378

  Fly   382 FMFCVTSLSYYVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVI---MLRFTGRRLTTMFLFLWT 443
            ||....::|.:..|::..:||.:   .|:...|:...:.||.||   :|...|||:|.:.|....
Mouse   379 FMRLFFTVSIFGLAVHLQHLSSN---IILLQFLISALAILVSVIGPFVLNHIGRRITYLVLMSLR 440

  Fly   444 GVSLLLVLAVPAGSTTWIVAFAMLGRFGISA-TYSVVTLYTAELYPTQIRNSALGTCSTFAHVGS 507
            |:.:|:.:.||....|..:..|.|.. |||: ...|..|:|.||.||.:|.:|:|....|.:.||
Mouse   441 GIFILIAVFVPQEMQTLRIIMATLAE-GISSLCVGVSRLHTNELLPTTLRATAVGVIGFFGNSGS 504

  Fly   508 ISAPYVVDVLGALGWYIPTTICGCCVLVAGLLTLTLPETGTGKLSD 553
            ..:|..: :|......:|....|...:........||||....|.|
Mouse   505 FLSPLFM-LLATYYANMPWIFYGGFSIFNAFTVFLLPETKNQPLPD 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	95/392 (24%)
Slc22a27	XP_017173565.1	MFS_OAT	134..540	CDD:340932	104/431 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843842
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940