Protein Alignment CG6356 and SLC22A12

DIOPT Version :9

• Sequence 1: NP_651240.1
• Gene: CG6356 / 42893
• FlyBaseID: FBgn0039178
• Length: 570
• Species: Drosophila melanogaster
• Sequence 2: XP_006718493.1
• Gene: SLC22A12 / 116085
• HGNCID: 17989
• Length: 578
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 149/619 - (24%)
• Similarity: 246/619 - (39%)
• Gaps: 162/619 - (26%)

  Fly    28 LEVVGSGGAF--------VWAIFFLCVTPNILNGFH--VSSY--------------TLLGHLPDD 68
            |::||..|.|        :.:|.:|| |.::|..|.  |.|:              ::||.|..:
Human     7 LDLVGGLGRFQVLQTMALMVSIMWLC-TQSMLENFSAAVPSHRCWAPLLDNSTAQASILGSLSPE 70

  Fly    69 ------------------------QWCGI-PELQDTNWTHAQKREIVAKGLDSGGCTVWDWNYGH 108
                                    ||..: |....|:|:.|          |:..| |..|.|..
Human    71 ALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEA----------DTEPC-VDGWVYDR 124

  Fly   109 LAKMSYEAALNYTGHLTQISPPAEVSCRVKGQHEFAHPETTFVADWDLTCDRSIQRTSAQVSISL 173
            ....|                                   |.||.|:|.||....:..||.....
Human   125 SIFTS-----------------------------------TIVAKWNLVCDSHALKPMAQSIYLA 154

  Fly   174 GKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCTFSPWYSLFLAGRFALGAASSGLFYPAFT 238
            |...|:.:.|..:|:|||:...|.......|......|:|.:.::...||.|..|.:|:.....|
Human   155 GILVGAAACGPASDRFGRRLVLTWSYLQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGT 219

  Fly   239 MIVENICLKHRSWMSIAFSASYPVGMI---------------------------ILAIVGYVIQP 276
             :..::..:|...:. |.|.:.|:|::                           :.|.|.|.::.
Human   220 -LRRSLTWRHAGGLH-AGSRAEPLGLLAVMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRD 282

  Fly   277 WRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVASDK 341
            |..|||.:::|..|..|..:.::||.|||:|..|.|...:.|:|          |||.:...:.:
Human   283 WTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWR----------VAAINGKGAVQ 337

  Fly   342 KSLEPE-------EGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSL-------SYY 392
            .:|.||       |..|.||     |..|:..|.....:|       |..|:::|       :::
Human   338 DTLTPEVLLSAMREELSMGQ-----PPASLGTLLRMPGLR-------FRTCISTLCWFAFGFTFF 390

  Fly   393 VTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGS 457
            ..||:...|..:.:|..:..|:||||:.:..:::|...|||.|.....|..|:.:|....||...
Human   391 GLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEM 455

  Fly   458 TTWIVAFAMLGRFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGW 522
            .....|.|:||..|:.|.::.:|:|::||:||.:|.:|:|.....|..|:|..| :|.:||..|.
Human   456 GALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGP-LVRLLGVHGP 519

  Fly   523 YIPTTICGCCVLVAGLLTLTLPETGTGKLSDKVE 556
            ::|..:.|...:::||..|.||||.:..|.|.::
Human   520 WLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQ 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	108/417 (26%)
SLC22A12	XP_006718493.1	2A0119	11..551	CDD:273328	146/611 (24%)
		MFS	122..541	CDD:119392	117/478 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153246
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950