DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and Slc22a13

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	NP_598741.2	Gene:	Slc22a13 / 102570	MGIID:	2143107	Length:	551	Species:	Mus musculus

Alignment Length:	550	Identity:	136/550 - (24%)
Similarity:	242/550 - (44%)	Gaps:	58/550 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWT-HAQKREIVAKGL 94
            ||..|.|...:..|...||.|..|.:.....: .|.:...|.:..:::..:. .|.::..::...
Mouse    11 VGDFGRFQVRLTILMGIPNFLAAFFIFGQVFM-VLDEAHHCSVSWVKNHTFNLSAAEQLAISIPN 74

  Fly    95 DSGGCTVWDWNYGHLAKMSYEAALNYTGHLTQISPPAEVSCRVKGQHEF----------AHPET- 148
            |:.|              ..|:.|.:.      .||...|......|.|          .:||.
Mouse    75 DTAG--------------RPESCLMFR------PPPDSASLEDILSHRFNETQACDSGWDYPENR 119

  Fly   149 --TFVADWDLTCDR-SIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSFTLGAAFFIVGSFFCT 210
              :...::||.||| ::::||..|.:: |...|:..||.:.|..||:.|..:......:.|....
Mouse   120 PQSLKKEFDLVCDRKNLKKTSQSVFMA-GLLVGALVFGPVCDWIGRRPSLLMQVLLSGITSMATA 183

  Fly   211 FSPWYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHRSWMSIAFSASYPVGMIILAIVGYVIQ 275
            |...:.|:||.||.|..|::|.......:|.|.:....|:...:...::..:|.::||.:.|.::
Mouse   184 FVSSFELYLALRFVLATANAGFLLSTNVLISEWVGPSWRTQAVVLAQSNVALGQMVLAGLAYGVR 248

  Fly   276 PWRHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVASD 340
            .||.||:..|.|.|||....:::.||||||::..|.:...::         :|.|.....:..|.
Mouse   249 NWRLLQITGTAPVLLLFFYFWVLPESPRWLLSQGRTEEAKQL---------VQKAALVNGRPLSP 304

  Fly   341 K--KSLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAANLSV 403
            :  ..|.||         |.||..:.::|:.:..:|::......::.|.||.||..:....:..:
Mouse   305 ELLNQLVPE---------KTGPSGNALDLFRHPHLRKVTLILIAVWFVDSLVYYSLSFQVGDFGL 360

  Fly   404 SRYLYIIGTGLVDIPSYLVPVIMLRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWIVAFAMLG 468
            ..|:..:..|.|::|...:.|:|:...||:.:.:......|:..::::.:|....|.:...|::|
Mouse   361 DIYVTQLIFGAVEMPGRFLSVLMMEKLGRKWSQLCTLTLAGIMYIIIIFIPGDLPTVVTVLAVVG 425

  Fly   469 RFGISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGCCV 533
            :|..:|.:::..:|||||:||.||.:.:|..|.|:.||.|..|.|: :|......||..|.|...
Mouse   426 KFASAAAFTISYVYTAELFPTIIRQTGMGLVSIFSRVGGIITPLVM-LLEQYHQAIPMVIFGSLP 489

  Fly   534 LVAGLLTLTLPETGTGKLSDKVESSASSTP 563
            :.||||...||||....|.|.::......|
Mouse   490 IGAGLLCALLPETRGQTLKDTLQDLEQGLP 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	99/378 (26%)
Slc22a13	NP_598741.2	2A0119	12..510	CDD:273328	133/538 (25%)
Slc22a13	NP_598741.2	MFS	139..500	CDD:119392	101/380 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843768
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	6.910