DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and slc22a7b.2

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_001337343.1	Gene:	slc22a7b.2 / 100001838	ZFINID:	ZDB-GENE-030131-9391	Length:	556	Species:	Danio rerio

Alignment Length:	584	Identity:	147/584 - (25%)
Similarity:	241/584 - (41%)	Gaps:	129/584 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KDLLTKQLEVVGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGH----LPDDQWCGIPELQDTNW 81
            :|||:   |:.|.|.   :....||:  |.|..|.:..:.|||:    :|... |.|..|.
Zfish     4 EDLLS---ELNGFGR---FQKMVLCI--NFLGRFSLGCHFLLGNFIAAIPSHH-CNISSLD---- 55

  Fly    82 THAQKREIVAKGLDSGGCTVWDWNYGHLAKMSYEAALNYTGHLTQISPPAE-----VSCRVKGQH 141
                        :|           |....:|.|..|.       :..||:     .||     |
Zfish    56 ------------VD-----------GVFENLSQEERLT-------VGVPAQEDGTPASC-----H 85

  Fly   142 EFAHPE--------------------------TTFVA----DWDLTCDRSIQRTSAQVSISLGKF 176
            .|:||:                          :||::    .|||.||:............||..
Zfish    86 MFSHPQFQLLINSSSSSDLPVVECQNGWHFDNSTFISTLATQWDLVCDKRALGKLTTTIFFLGVM 150

  Fly   177 CGSFSFGILADKFGRKS----SFTLGAAFFIVGSFFCT-FSPWYSLFLAGRFALGAASSGLFYPA 236
            .|:.:||.|:..||||.    |:.||..|.:     |: .|....:|...||..|...:|....:
Zfish   151 FGAAAFGSLSAMFGRKPMLLVSYILGMGFGL-----CSVLSSSLVMFAVLRFFSGFTITGSVIIS 210

  Fly   237 FTMIVENICLKHRSWMSIAFSASYPVGMIILAIVGYVIQPWRHLQLALTIPSLLLILNCYLMSES 301
            ..:.||.:.::||..:.:..|.::..|.:...::.|.|:.||.|.:|:::|:::.|:..:.:.||
Zfish   211 TVLNVEWVSIEHRKLVGVIDSLAWTFGFMGFPVIAYFIRDWRWLTVAISLPNVISIITWWWVPES 275

  Fly   302 PRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVASDKKS----LEPEEGFSFGQKLKNGPLK 362
            .||||.|.:.|:         :||.::...|     .:.||.    ::||:........:.....
Zfish   276 ARWLIVNGKADK---------AHYYLKKCAA-----MNHKKEVTARIKPEDLSKIIVTDRGSRKY 326

  Fly   363 SIIELYANSKVRRM-IFASYFMFCVTSLSYYVTALNAANLSVSRYLYIIGTGLVDIPSYLVPVIM 426
            |.::|....|:||: :......|.|.:::|.: :.|.....::.||.....|.::||:......:
Zfish   327 SYLDLVRTPKMRRLSLLTGITWFSVATVAYGI-SFNITGFGLNMYLTQFVYGAIEIPAKFCIYYL 390

  Fly   427 LRFTGRRLTTMFLFLWTGVSLLLVLAVPAGSTTWIVAFAMLGRFGISAT-YSVVTLYTAELYPTQ 490
            |...||.:|.....|:.|:|.::.:.:|...|......|:||: |.||| :..|.|||:|||||.
Zfish   391 LDKFGRHVTQAGSLLFVGISFIINIFIPKEKTVIRTVIAVLGK-GCSATSFGTVILYTSELYPTV 454

  Fly   491 IRNSALGTCSTFAHVGSISAPYVV---DVLGALGW-YIPTTICGCCVLVAGLLTLTLPETGTGK 550
            :|.:.:|..|..|..|...||.::   ||     | |....|.....|.|..:...|||| :||
Zfish   455 VRQNGMGYTSFIARFGVSVAPLILLSNDV-----WSYFSQVILCFLALSAAFVAYQLPET-SGK 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	103/391 (26%)
slc22a7b.2	XP_001337343.1	2A0119	12..517	CDD:273328	143/573 (25%)
slc22a7b.2	XP_001337343.1	MFS	140..504	CDD:119392	103/389 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588948
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.940