DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6356 and slc22a5

DIOPT Version :9

Sequence 1:	NP_651240.1	Gene:	CG6356 / 42893	FlyBaseID:	FBgn0039178	Length:	570	Species:	Drosophila melanogaster
Sequence 2:	XP_021324939.1	Gene:	slc22a5 / 100000685	ZFINID:	ZDB-GENE-091012-1	Length:	549	Species:	Danio rerio

Alignment Length:	554	Identity:	159/554 - (28%)
Similarity:	258/554 - (46%)	Gaps:	45/554 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VGSGGAFVWAIFFLCVTPNILNGFHVSSYTLLGHLPDDQWCGIPELQDTNWTHAQ-KREIVAKG- 93
            :|..|.|...:|.|.....|..|.|......:...|..: |.:......:|..|. ..|.::.|
Zfish    11 LGQTGPFFIRLFCLLNLIYISTGLHGLYIVFVAASPAHR-CRVDVNLTEDWLEASAPTETLSNGD 74

  Fly    94 LDSGGCTVWDWNYGHLAKMSYEAALNYTG--------HLTQISPPAEVSCRVKGQHEFAHPETTF 150
            |....|    |.|      |.:...|.:|        ::|.|  |.| .|.....:......:|.
Zfish    75 LQVSQC----WRY------SLQTLTNLSGQGYSPGQINITDI--PRE-RCEDGWVYSADVYHSTI 126

  Fly   151 VADWDLTCDRSIQRTSAQVSISLGKFCGSFSFGILADKFGRKSSF--TLGAAFFIVGSFFCTFSP 213
            |::|||.||...:...|..::.:|...||...|.|:|:||||...  :|.|...::  |..:|||
Zfish   127 VSEWDLVCDSEWRVPLASSTLYMGYLLGSIVSGQLSDRFGRKKVLFGSLAAEALLM--FAQSFSP 189

  Fly   214 WYSLFLAGRFALGAASSGLFYPAFTMIVENICLKHR-SWMSIAFSASYPVGMIILAIVGYVIQPW 277
            .:.:|....|.:||....|:..||.:..|.:....| .:.::.....|.||.::|..|.:.|:.|
Zfish   190 SWLIFCVLYFFIGAFQISLYITAFVLGNEVLSGSLRVLFTTLGAFLHYCVGYMLLPWVAFAIRHW 254

  Fly   278 RHLQLALTIPSLLLILNCYLMSESPRWLITNQRYDRVYKILFRQPSHYQIQPAVAAPSQVASDKK 342
            |.|...|:..:::.|...:|:.||||||: :|.:.:..:.:.|..:.   :..|.||..:.  |:
Zfish   255 RTLLRVLSGLTVVYIPLWWLIPESPRWLL-SQGHVQESEAILRDAAR---KNRVPAPEVIF--KQ 313

  Fly   343 SLEPEEGFSFGQKLKNGPLKSIIELYANSKVRRMIFASYFMFCVTSLSYYVTALNAANLSVSRYL 407
            |...|..|   ||.|    .|.:::...|.:||..|....::...::.|:..:||..|||...:|
Zfish   314 SQIKEAAF---QKSK----YSALDVLRTSNIRRTTFMCLLLWMAINIGYFGLSLNTTNLSGDPFL 371

  Fly   408 YIIGTGLVDIPSYLVPVIMLRFTGRR-LTTMFLFLWTGVSLLLVLAVPAGSTTWIVAFAMLGRFG 471
            ....:.:.::|:|:|...:|:...|| :.:.||.:..|. ||||..:|....|..:|..|.|:||
Zfish   372 NCFLSAVTEVPAYIVSTFLLKSCPRRPVLSAFLVIGGGF-LLLVQLIPDRLQTLALALEMAGKFG 435

  Fly   472 ISATYSVVTLYTAELYPTQIRNSALGTCSTFAHVGSISAPYVVDVLGALGWYIPTTICGCCVLVA 536
            .:.:::||.:||||||||.:||..:|.||:.|.:|||:|||:: .||....::|..:.|...:.|
Zfish   436 FTMSFTVVYIYTAELYPTVLRNLGMGMCSSAARIGSITAPYII-FLGTFNRHLPYVLMGSLTITA 499

  Fly   537 GLLTLTLPETGTGKLSDKVESSASSTPTEPAEKQ 570
            .|..|.||||....|.:.:|....|......:||
Zfish   500 SLANLFLPETFGKVLPENLEQMQKSRSFPGRDKQ 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6356	NP_651240.1	MFS	167..544	CDD:119392	117/380 (31%)
slc22a5	XP_021324939.1	Sugar_tr	12..516	CDD:331684	155/534 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	5.010