Protein Alignment shps and MAOB

DIOPT Version :10

• Sequence 1: NP_651239.1
• Gene: shps / 42892
• FlyBaseID: FBgn0286199
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_000889.3
• Gene: MAOB / 4129
• HGNCID: 6834
• Length: 520
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 114/542 - (21%)
• Similarity: 204/542 - (37%)
• Gaps: 125/542 - (23%)

  Fly    13 DVLIVGGGLSGLASALKILAMESTLKVRMIEASDALGG------------------LMGQNSTRL 59
            ||::||||:||:|:| |:| .:|.|.|.::||.|.:||                  .:|....|:
Human     6 DVVVVGGGISGMAAA-KLL-HDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRI 68

  Fly    60 VDAAQQDMLALLT--------LIHLSPRRRRSISGSLRRCWD----LDRGLTAMPAKFELGRYID 112
            :..|::  |.|.|        |||....:.....|.....|:    ||..        ...|.:|
Human    69 LRLAKE--LGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHN--------NFWRTMD 123

  Fly   113 MLDLRMPKFRSKRFNLRERVSNME-QHICHHLFFSKSRNFMLNL-VQLVCGVPANEVDYDVFMSV 175
            .:...:|.....:..|.|...||. :.:...|.:::|...:..| |.|......:||....|:..
Human   124 DMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWY 188

  Fly   176 CSSCGGLKVLIDFYFTYPTSFYEISTQMLIENILEQLQFIKIILNCRAVRLEHFKNYVQVTDDQG 240
            ...|||...:|..........:...:..:.|.|::.|. .::.|....:.::..:..|.|.....
Human   189 VKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLG-DRVKLERPVIYIDQTRENVLVETLNH 252

  Fly   241 NKHTAQAAILAIPWNKVQKLHFEPRIPKVFLPRTTSRSGRKGRQVISQFQL--------RYGKSV 297
            ..:.|:..|.|||.....|:||.|.:|.:            ..|:|::..|        .|.:..
Human   253 EMYEAKYVISAIPPTLGMKIHFNPPLPMM------------RNQMITRVPLGSVIKCIVYYKEPF 305

  Fly   298 WTDLGYSGNFLSSQPMVSGHEC-------------RMSSFCGYVL-HLPE-----DQDEVLQDVV 343
            |....|.|..:     :.|.|.             ..::..|::| |...     .::|.|:.:.
Human   306 WRKKDYCGTMI-----IDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLC 365

  Fly   344 DLLAEHFGE-EMRQPLE------CQ------CFTDELN---VAQH-KPQTKPWHRVIWSSSSAVG 391
            :|.|:..|. |..:|:.      |:      |:|....   :.|: :...:|..| |:.:.:...
Human   366 ELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDR-IYFAGTETA 429

  Fly   392 TSYRSLMGGAVQSGFRAAVNAVFVVR--PQVVSWKDMLVEQPKN----GQDVVSA------GRIR 444
            |.:...|.|||::|.|||...:..:.  |:...|:    .:|::    .|.:.:.      ..:.
Human   430 THWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQ----SEPESVDVPAQPITTTFLERHLPSVP 490

  Fly   445 GLLSRLNLYNVTFYSFFVIGLI 466
            |||..:.|  .|.:|...:|.:
Human   491 GLLRLIGL--TTIFSATALGFL 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shps	NP_651239.1	YobN	9..409	CDD:440844	101/471 (21%)
MAOB	NP_000889.3	YobN	14..455	CDD:440844	97/471 (21%)