Protein Alignment shps and MAOA

DIOPT Version :10

• Sequence 1: NP_651239.1
• Gene: shps / 42892
• FlyBaseID: FBgn0286199
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_000231.1
• Gene: MAOA / 4128
• HGNCID: 6833
• Length: 527
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 112/570 - (19%)
• Similarity: 212/570 - (37%)
• Gaps: 178/570 - (31%)

  Fly    13 DVLIVGGGLSGLASALKILAMESTLKVRMIEASDALGG------------------LMGQNSTRL 59
            ||:::|||:||| ||.|:|. |..:.|.::||.|.:||                  .:|....|:
Human    15 DVVVIGGGISGL-SAAKLLT-EYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRI 77

  Fly    60 VDAAQQDMLALLTL-IHLSPR-------RRRSISGSLRRCWDLDRGLTAMPAKF----ELGRYID 112
            :..:::  |.:.|. :::|.|       :.....|:....|:        |..:    .|.|.||
Human    78 LRLSKE--LGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWN--------PIAYLDYNNLWRTID 132

  Fly   113 MLDLRMP---KFRSKRFNLRERVSNME--QHICHHLFFSKSRNFMLNLVQLVCGVPANEVDYDVF 172
            .:...:|   .:.::..:..::::..|  ..||   :...:|.|....|.:......:||....|
Human   133 NMGKEIPTDAPWEAQHADKWDKMTMKELIDKIC---WTKTARRFAYLFVNINVTSEPHEVSALWF 194

  Fly   173 MSVCSSCGGLKVLIDFYFTYPTSFYEIS-----------TQMLIENILEQLQFIKIILNCRAVRL 226
            :.....|||           .|..:.::           :..:.|.|::.|.        ..|:|
Human   195 LWYVKQCGG-----------TTRIFSVTNGGQERKFVGGSGQVSERIMDLLG--------DQVKL 240

  Fly   227 EHFKNYVQVTDDQ------GNKH-TAQAAILAIPWNKVQKLHFEPRIPKVFLPRTTSRSGRKGRQ 284
            .|...:|..:.|.      .::| ..:..|.|||.....|:||.|.:|            .:..|
Human   241 NHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELP------------AERNQ 293

  Fly   285 VISQF--------QLRYGKSVWTDLGYSGNFL-------------SSQPMVSGHECRMSSFCGYV 328
            :|.:.        .:.|.::.|....|.|..:             .::|     :..:.:..|::
Human   294 LIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKP-----DGSLPAIMGFI 353

  Fly   329 LHLPEDQDEVL------QDVVDLLAEHFG-EEMRQPLE------CQ------CFTDELNVAQHKP 374
            |....|:...|      :.:.:|.|:..| :|...|:.      |:      |:|     |...|
Human   354 LARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYT-----AYFPP 413

  Fly   375 Q---------TKPWHRVIWSSSSAVGTSYRSLMGGAVQSGFRAA---VNAVFVVRPQVVSWKDML 427
            .         .:|..|:.::.:. ..|.:...|.|||::|.|||   :|.:     ..|:.||:.
Human   414 GIMTQYGRVIRQPVGRIFFAGTE-TATKWSGYMEGAVEAGERAAREVLNGL-----GKVTEKDIW 472

  Fly   428 VEQPKNGQDVVSAGRIRGLLSRLNLYNVTFYSFFVIGLIWLLNLGYARSI 477
            |::|::..  |.|..|.......||.:|:       ||:.:  :|::.|:
Human   473 VQEPESKD--VPAVEITHTFWERNLPSVS-------GLLKI--IGFSTSV 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shps	NP_651239.1	YobN	9..409	CDD:440844	94/497 (19%)
MAOA	NP_000231.1	YobN	11..464	CDD:440844	97/510 (19%)
		Interaction with membrane phospholipid headgroups. /evidence=ECO:0000305	520..522