DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shps and KDM1A

DIOPT Version :9

Sequence 1:	NP_651239.1	Gene:	shps / 42892	FlyBaseID:	FBgn0286199	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	XP_006710537.1	Gene:	KDM1A / 23028	HGNCID:	29079	Length:	878	Species:	Homo sapiens

Alignment Length:	451	Identity:	79/451 - (17%)
Similarity:	153/451 - (33%)	Gaps:	151/451 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VLIVGGGLSGLASA--LKILAMESTLKVRMIEASDALGGLMG--QNSTRLVDAAQQDMLAL--LT 72
            |:|:|.|:||||:|  |:...|:.||    :||.|.:||.:.  :....:.|.....:..|  ..
Human   301 VIIIGSGVSGLAAARQLQSFGMDVTL----LEARDRVGGRVATFRKGNYVADLGAMVVTGLGGNP 361

  Fly    73 LIHLSPRRRRSISGSLRRCWDLDRGLTAMPAKFELGRYIDMLDLRMPKFRSKRFNLRERVSNMEQ 137
            :..:|.:....::...::|...:....|:|.:.:     :|::        :.||   |:.....
Human   362 MAVVSKQVNMELAKIKQKCPLYEANGQAVPKEKD-----EMVE--------QEFN---RLLEATS 410

  Fly   138 HICHHLFFSKSRNFMLNLVQLVCGVPANEVDYDVFMSVCSSCGGLKVLIDFYFTYPTSFYEISTQ 202
            ::.|.|.|:...|..::|.|.:                                      |:..|
Human   411 YLSHQLDFNVLNNKPVSLGQAL--------------------------------------EVVIQ 437

  Fly   203 MLIENILEQLQFIKIILNCRAVRLEHFKNYVQVTDDQGNKHTAQAAILAIPWNKVQKLHFEPRIP 267
            :..:::.::             ::||:|..|:..::           |....||:  ::.:.:|.
Human   438 LQEKHVKDE-------------QIEHWKKIVKTQEE-----------LKELLNKM--VNLKEKIK 476

  Fly   268 KVFLPRTTSRSGRKGRQVISQFQLRYGKSVWTDLGYSGNFLSSQPMVSGHECRMSSFCGYVLHLP 332
            ::......:...:..|.:.::|.:   ||...||                    ::.|
Human   477 ELHQQYKEASEVKPPRDITAEFLV---KSKHRDL--------------------TALC------- 511

  Fly   333 EDQDEVLQDVVDLLAEHFG--EEMRQPLECQ-----CFTDELNVAQHKPQTKPWHRVIWSSSSAV 390
            ::.||        |||..|  ||..|.||..     .|..::.::....|...||......::|.
Human   512 KEYDE--------LAETQGKLEEKLQELEANPPSPLFFCSDVYLSSRDRQILDWHFANLEFANAT 568

  Fly   391 GTSYRSLMGGAVQSGFRAAVNAVFVVRPQVVSWKDMLVEQPKNGQDVVSAGRIRGLLSRLN 451
            ..|..||........|....:.:.|                :||...|......||..:||
Human   569 PLSTLSLKHWDQDDDFEFTGSHLTV----------------RNGYSCVPVALAEGLDIKLN 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shps	NP_651239.1	NADB_Rossmann	11..>53	CDD:304358	18/40 (45%)
shps	NP_651239.1	Amino_oxidase	21..409	CDD:279874	67/400 (17%)
KDM1A	XP_006710537.1	SWIRM	197..284	CDD:282311
		NAD_binding_8	303..361	CDD:290186	19/61 (31%)
		Amino_oxidase	308..851	CDD:279874	75/444 (17%)
		SurA_N_3	<395..491	CDD:304439	20/175 (11%)
		NAT_SF	<441..>549	CDD:302625	27/171 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1231
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900