Protein Alignment shps and KDM1B

DIOPT Version :10

• Sequence 1: NP_651239.1
• Gene: shps / 42892
• FlyBaseID: FBgn0286199
• Length: 477
• Species: Drosophila melanogaster
• Sequence 2: NP_001426046.1
• Gene: KDM1B / 221656
• HGNCID: 21577
• Length: 832
• Species: Homo sapiens
• Alignment Length: 473
• Identity: 97/473 - (20%)
• Similarity: 177/473 - (37%)
• Gaps: 114/473 - (24%)

  Fly    14 VLIVGGGLSGLASALKILAMESTLKVRMIEASDALGGLMGQNST----------RLVDAAQQDML 68
            |:|:|.|.:|||:|.::  ....:||.::||.|.:||.:..:.:          ::|:....:.:
Human   394 VIIIGAGPAGLAAARQL--HNFGIKVTVLEAKDRIGGRVWDDKSFKGVTVGRGAQIVNGCINNPV 456

  Fly    69 ALLTLIHLSPRRRRSISGSL----RRCWDL--DRGLTAMPA-----KFELGRYIDML-DLRMPKF 121
            ||:.         ..:..|:    .|| ||  :.|....|.     .|.....:|:: :.|..|.
Human   457 ALMC---------EQLGISMHKFGERC-DLIQEGGRITDPTIDKRMDFHFNALLDVVSEWRKDKT 511

  Fly   122 RSKRFNLRERVSNMEQHICHHLFFSKS-----------RNFMLNLVQLVCG-----VPANEVDYD 170
            :.:...|.|::..:     :..|..:|           ..|.|:.::..||     |.|...|::
Human   512 QLQDVPLGEKIEEI-----YKAFIKESGIQFSELEGQVLQFHLSNLEYACGSNLHQVSARSWDHN 571

  Fly   171 VFMSVCSSCGGLKVLIDFYFTYPTSFYEISTQMLIENILEQLQFIKIILNCRAVRLEHFKNYVQV 235
            .|.   :...|...|:       |..|.:..:.|.|.:..||:..::  .|    :::..:.|||
Human   572 EFF---AQFAGDHTLL-------TPGYSVIIEKLAEGLDIQLKSPQV--QC----IDYSGDEVQV 620

  Fly   236 TDDQGNKHTAQAAILAIPWNKVQK--LHFEPRIPKVFLPRTTSRSGRKGRQVISQFQLRYGKSVW 298
            |...|..::||..::.:|...:||  :.|.|.:.:..:....|    .|..:|.:..|::....|
Human   621 TTTDGTGYSAQKVLVTVPLALLQKGAIQFNPPLSEKKMKAINS----LGAGIIEKIALQFPYRFW 681

  Fly   299 TDLGYSGNFLSSQPMVSG----------------HECRMSSFCGYVLHLPE--DQDEVLQDVVDL 345
            .......:|....|..:.                |...||...|..:....  |..:|||..:..
Human   682 DSKVQGADFFGHVPPSASKRGLFAVFYDMDPQKKHSVLMSVIAGEAVASVRTLDDKQVLQQCMAT 746

  Fly   346 LAEHFGEEMRQPLECQCFTDELNVAQHKPQTKPWHRVIWS--SSSAVGTSY----RSLMGGAVQS 404
            |.|.| :|...|...:.|....:       |.||.::.:|  .:...|.:|    ..:.|....:
Human   747 LRELF-KEQEVPDPTKYFVTRWS-------TDPWIQMAYSFVKTGGSGEAYDIIAEDIQGTVFFA 803

  Fly   405 GFRAAVNAVFVVRPQVVS 422
            |  .|.|..|   ||.|:
Human   804 G--EATNRHF---PQTVT 816

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
shps	NP_651239.1	YobN	9..409	CDD:440844	91/458 (20%)
KDM1B	NP_001426046.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	282..301
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	447..476		6/38 (16%)
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	496..507		1/10 (10%)
		Histone H3-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0000269|PubMed:23266887, ECO:0007744|PDB:4FWF, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS	547..581		9/36 (25%)
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	573..575		1/4 (25%)
		GLYR1-binding. /evidence=ECO:0000269|PubMed:23260659, ECO:0007744|PDB:4GUR, ECO:0007744|PDB:4GUS, ECO:0007744|PDB:4GUT, ECO:0007744|PDB:4GUU	808..824		5/12 (42%)