DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shps and Maoa

DIOPT Version :9

Sequence 1:	NP_651239.1	Gene:	shps / 42892	FlyBaseID:	FBgn0286199	Length:	477	Species:	Drosophila melanogaster
Sequence 2:	NP_776101.3	Gene:	Maoa / 17161	MGIID:	96915	Length:	526	Species:	Mus musculus

Alignment Length:	549	Identity:	117/549 - (21%)
Similarity:	213/549 - (38%)	Gaps:	137/549 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DVLIVGGGLSGLASALKILAMESTLKVRMIEASDALGG------------------LMGQNSTRL 59
            ||:::|||:||||:| |:|: |..:.|.::||.|.:||                  .:|....|:
Mouse    15 DVVVIGGGISGLAAA-KLLS-EYKINVLVLEARDRVGGRTYTVRNEHVKWVDVGGAYVGPTQNRI 77

  Fly    60 VDAAQQDMLALLT--------LIHLSPRRRRSISGSLRRCWDLDRGLTAMPAKF----ELGRYID 112
            :..:::  |.:.|        |:.....:.....|:....|:        |..:    .|.|.:|
Mouse    78 LRLSKE--LGIETYKVNVNERLVQYVKGKTYPFRGAFPPVWN--------PLAYLDYNNLWRTMD 132

  Fly   113 MLDLRMP---KFRSKRFNLRERVS--NMEQHICHHLFFSKSRNFMLNLVQLVCGVPANEVDYDVF 172
            .:...:|   .::::.....::::  ::...||   :...:|.|....|.:......:||....|
Mouse   133 DMGKEIPVDAPWQARHAEEWDKITMKDLIDKIC---WTKTAREFAYLFVNINVTSEPHEVSALWF 194

  Fly   173 MSVCSSCGGLKVLIDFYFT---YPTSFYEISTQMLIENILEQLQFIKIILNCRAVRLEHFKNYVQ 234
            :.....|||...:  |..|   ....|...|.|     |.||   |.::|..: |:|.....|:.
Mouse   195 LWYVRQCGGTSRI--FSVTNGGQERKFVGGSGQ-----ISEQ---IMVLLGDK-VKLSSPVTYID 248

  Fly   235 VTDDQ------GNKH-TAQAAILAIPWNKVQKLHFEPRIPKVFLPRTTSRSGRKGRQVISQFQLR 292
            .|||.      .::| ..:..|.|||.....|:||:|.:|    |.......|.....:.:..:.
Mouse   249 QTDDNIIIETLNHEHYECKYVISAIPPVLTAKIHFKPELP----PERNQLIQRLPMGAVIKCMVY 309

  Fly   293 YGKSVWTDLGYSGNFL-------------SSQPMVSGHECRMSSFCGYVLHLPED------QDEV 338
            |.::.|....|.|..:             .::|     :..|.:..|::|....:      :|..
Mouse   310 YKEAFWKKKDYCGCMIIEDEEAPISITLDDTKP-----DGSMPAIMGFILARKAERLAKLHKDIR 369

  Fly   339 LQDVVDLLAEHFG-EEMRQPLE------CQ------CFTDELNVAQHKPQTKP-WHRV------- 382
            .:.:.:|.|:..| :|...|:.      |:      |:|     |...|.... :.||
Mouse   370 KRKICELYAKVLGSQEALSPVHYEEKNWCEEQYSGGCYT-----AYFPPGIMTLYGRVIRQPVGR 429

  Fly   383 IWSSSSAVGTSYRSLMGGAVQSGFRAA---VNAVFVVRPQVVSWKDMLVEQPKN----GQDVVSA 440
            |:.:.:...|.:...|.|||::|.|||   :||:     ..|:.||:.|::|::    ..::...
Mouse   430 IYFAGTETATQWSGYMEGAVEAGERAAREVLNAL-----GKVAKKDIWVQEPESKDVPALEITHT 489

  Fly   441 GRIRGLLSRLNLYNVTFYSFFVIGLIWLL 469
            ...|.|.|...|..:|.:|..|..|.::|
Mouse   490 FLERNLPSVPGLLKITGFSTSVALLCFVL 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shps	NP_651239.1	NADB_Rossmann	11..>53	CDD:304358	19/57 (33%)
shps	NP_651239.1	Amino_oxidase	21..409	CDD:279874	94/472 (20%)
Maoa	NP_776101.3	YobN	15..463	CDD:224152	102/487 (21%)
		NAD_binding_8	18..84	CDD:290186	19/69 (28%)
		Interaction with membrane phospholipid headgroups. /evidence=ECO:0000250	520..522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839593
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1231
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D484748at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750