DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and SLC22A13

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_004247.2	Gene:	SLC22A13 / 9390	HGNCID:	8494	Length:	551	Species:	Homo sapiens

Alignment Length:	552	Identity:	197/552 - (35%)
Similarity:	300/552 - (54%)	Gaps:	41/552 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWNLSY 70
            |:..:|:||.:|.::..|||:...:..|:..|.||::......||:.:       :..|.:|||.
Human     7 VLAEIGDFGRFQIQLLILLCVLNFLSPFYFFAHVFMVLDEPHHCAVAW-------VKNHTFNLSA 64

  Fly    71 PEN-------------ERCSYYDVDYTEEYLNGSIPRSSNETKTCS-SYVYDRSKYLNSAVTEWN 121
            .|.             |.|..:........|...:....|||:.|. .:.|..:: |.|...|:|
Human    65 AEQLVLSVPLDTAGHPEPCLMFRPPPANASLQDILSHRFNETQPCDMGWEYPENR-LPSLKNEFN 128

  Fly   122 LVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTI 186
            |||.|..|..|:.|:||.|:|:|:|:||.:.|::|||.|..|.|:|..:.|:..|..|.:..|..
Human   129 LVCDRKHLKDTTQSVFMAGLLVGTLMFGPLCDRIGRKATILAQLLLFTLIGLATAFVPSFELYMA 193

  Fly   187 SRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAIT 251
            .|..|....:|:......:..|.||.|:|..|.|..|..||:|.|:.||.||...:||.|||..|
Human   194 LRFAVATAVAGLSFSNVTLLTEWVGPSWRTQAVVLAQCNFSLGQMVLAGLAYGFRNWRLLQITGT 258

  Fly   252 LPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEM 316
            .||||...|:|.:||||||||.:||.|||..:|:|||..|:.::..|:..|||.|
Human   259 APGLLLFFYFWALPESARWLLTRGRMDEAIQLIQKAASVNRRKLSPELMNQLVPE---------- 313

  Fly   317 AASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGY 381
             .:.|:....||.|:|.||:.||:||..|||:|..|||||....:.|.:..:..:|.||||:|..
Human   314 -KTGPSGNALDLFRHPQLRKVTLIIFCVWFVDSLGYYGLSLQVGDFGLDVYLTQLIFGAVEVPAR 377

  Fly   382 TLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAE 446
            ...:|.:.|:||:....||:::.|:..:..||:|:|:..::...|::||:|..:::...|::|||
Human   378 CSSIFMMQRFGRKWSQLGTLVLGGLMCIIIIFIPADLPVVVTMLAVVGKMATAAAFTISYVYSAE 442

  Fly   447 QFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPM 511
            .|||::|..|:|...:.:|:||||.|.:.||||....||::|.|:|.:.||||..|||||..:.:
Human   443 LFPTILRQTGMGLVGIFSRIGGILTPLVILLGEYHAALPMLIYGSLPIVAGLLCTLLPETHGQGL 507

  Fly   512 PETIEDGENFG-------KKPAPQETAEEGGT 536
            .:|::|.| .|       ..|:.:||..:|.|
Human   508 KDTLQDLE-LGPHPRSPKSVPSEKETEAKGRT 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	187/516 (36%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	140/355 (39%)
SLC22A13	NP_004247.2	2A0119	12..510	CDD:273328	187/516 (36%)
		MFS	139..500	CDD:119392	148/371 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..551		8/29 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153440
Domainoid	1	1.000	288	1.000	Domainoid score	I1580
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2390
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		otm41229
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.930