Protein Alignment Orct and SLC22A6

DIOPT Version :9

• Sequence 1: NP_001262908.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_004781.2
• Gene: SLC22A6 / 9356
• HGNCID: 10970
• Length: 563
• Species: Homo sapiens
• Alignment Length: 553
• Identity: 169/553 - (30%)
• Similarity: 284/553 - (51%)
• Gaps: 28/553 - (5%)

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYE-----NGSIYE 60
            |.::|::..:|..|.:|:....|:.||.::.|.|.....|..|.|...|..|.:     ||.:
Human     1 MAFNDLLQQVGGVGRFQQIQVTLVVLPLLLMASHNTLQNFTAAIPTHHCRPPADANLSKNGGL-- 63

  Fly    61 LSPHLWNLSYPEN-----ERC-SYYDVDYTEEYLNGSIPRSSNETKTCS-SYVYDRSKYLNSAVT 118
               .:|   .|.:     |.| .:....:...:|||:....:..|:.|: .::||.|.:.::.||
Human    64 ---EVW---LPRDRQGQPESCLRFTSPQWGLPFLNGTEANGTGATEPCTDGWIYDNSTFPSTIVT 122

  Fly   119 EWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFS 183
            ||:||||...|...:.||:|:|||||:::||.::|:|||:.....:.:...:.|..||.||.:..
Human   123 EWDLVCSHRALRQLAQSLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPI 187

  Fly   184 YTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQI 248
            |...|::.|...:|:.|....:.:|.:....|...|..:...:|:|..|.||.||.:..||.||:
Human   188 YCAFRLLSGMALAGISLNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAVPHWRHLQL 252

  Fly   249 AITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQ 313
            .::.|...|..|.|...|||||....||.|.....:::.|:.|.   ..|...:|..||.....|
Human   253 LVSAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARING---KREEGAKLSMEVLRASLQ 314

  Fly   314 DEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEI 378
            .|:...:..|:..:|||.|.||...|.:...||..|..||||..:....|.:..:..:|.|||::
Human   315 KELTMGKGQASAMELLRCPTLRHLFLCLSMLWFATSFAYYGLVMDLQGFGVSIYLIQVIFGAVDL 379

  Fly   379 PGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIF 443
            |...:....:|..|||......:::|||.:|....:|.|.:.:..:.|::||..:.:|:..|:::
Human   380 PAKLVGFLVINSLGRRPAQMAALLLAGICILLNGVIPQDQSIVRTSLAVLGKGCLAASFNCIFLY 444

  Fly   444 SAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLN 508
            :.|.:||::|..|:|..|.:||||.|::|.:.:..|::..:||.|.||:.:.|..:::||||||.
Human   445 TGELYPTMIRQTGMGMGSTMARVGSIVSPLVSMTAELYPSMPLFIYGAVPVAASAVTVLLPETLG 509

  Fly   509 KPMPETIEDGENFGKKPAPQETAEEGGTQELSG 541
            :|:|:|::|.|:   :.||  |.:|.|.....|
Human   510 QPLPDTVQDLES---RWAP--TQKEAGIYPRKG 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	158/514 (31%)
		MFS	135..491	CDD:119392	111/355 (31%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	158/514 (31%)
		MFS	135..505	CDD:119392	115/372 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..563		5/15 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153518
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	1	1.000	-	-		otm41229
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.980