DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and PHO84

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_013583.1	Gene:	PHO84 / 854916	SGDID:	S000004592	Length:	587	Species:	Saccharomyces cerevisiae

Alignment Length:	506	Identity:	115/506 - (22%)
Similarity:	191/506 - (37%)	Gaps:	128/506 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 TCSSYVYDRSKYLNSAVTEWNLVC---SRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFF 162
            |..||||            |:...   |::||..::.    :|.::|...||.::|.:|||..:.
Yeast    88 TMMSYVY------------WHGSMPGPSQTLLKVSTS----VGTVIGQFGFGTLADIVGRKRIYG 136

  Fly   163 ASLVLQLIFGVL---AAVAPE---YFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVA 221
            ..|::.::..:|   .|.:|.   ....|..|:::|....|.:.::.:|..|...:.:|   |..
Yeast   137 MELIIMIVCTILQTTVAHSPAINFVAVLTFYRIVMGIGIGGDYPLSSIITSEFATTKWR---GAI 198

  Fly   222 MQMFFS-----------VGFMLTAGFAYFI------------------HDWRWLQIAITLPGLLF 257
            |...|:           :..:|.|.:...:                  ..||.|....|:.||..
Yeast   199 MGAVFANQAWGQISGGIIALILVAAYKGELEYANSGAECDARCQKACDQMWRILIGLGTVLGLAC 263

  Fly   258 LCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQ-- 320
            |.:...||||.|:.|....|      :|.||...:.:...:|::...:::|....:....|.:
Yeast   264 LYFRLTIPESPRYQLDVNAK------LELAAAAQEQDGEKKIHDTSDEDMAINGLERASTAVESL 322

  Fly   321 ----PAATVFDLLRYPNLRR--KTLL-IFFDWFVNSGVYYGLSWN------TNNLGGNQLV---- 368
                |.|:..|..|:....:  |.|| ....||.....:||||.|      |....|::.|
Yeast   323 DNHPPKASFKDFCRHFGQWKYGKILLGTAGSWFTLDVAFYGLSLNSAVILQTIGYAGSKNVYKKL 387

  Fly   369 ------NFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNW------- 420
                  |.::..|..:|||.:.:||::..||:.|     .:||..:|..:|......:
Yeast   388 YDTAVGNLILICAGSLPGYWVSVFTVDIIGRKPI-----QLAGFIILTALFCVIGFAYHKLGDHG 447

  Fly   421 ---LIVACAMIGKLAITSSYG---TIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGE 479
               |.|.|...      .::|   |.:|...|.|||..|:...|.|:...:||.|:|.  ..||.
Yeast   448 LLALYVICQFF------QNFGPNTTTFIVPGECFPTRYRSTAHGISAASGKVGAIIAQ--TALGT 504

  Fly   480 I--------------WRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIE 516
            :              |.|..:.|.....|.....:||:|||..|.:.|..|
Yeast   505 LIDHNCARDGKPTNCWLPHVMEIFALFMLLGIFTTLLIPETKRKTLEEINE 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	113/502 (23%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	97/442 (22%)
PHO84	NP_013583.1	2A0109	49..554	CDD:129965	114/503 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344940
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
TreeFam	0	0.000	Not matched by this tool.
	4	3.870