Protein Alignment Orct and SLC22A16

DIOPT Version :10

• Sequence 1: NP_524479.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_149116.2
• Gene: SLC22A16 / 85413
• HGNCID: 20302
• Length: 577
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 183/598 - (30%)
• Similarity: 294/598 - (49%)
• Gaps: 81/598 - (13%)

  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALP--------------- 52
            ::.:..|:|.||.:|:.:|::.....|.|..|.||.||:...|...|..|
Human     6 FEGIYDHVGHFGRFQRVLYFICAFQNISCGIHYLASVFMGVTPHHVCRPPGNVSQVVFHNHSNWS 70

  Fly    53 -------------------YENGSIYELSPHLWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNE 98
                               .:||.|:|||    ..|..:.|..|....:||         .|..|
Human    71 LEDTGALLSSGQKDYVTVQLQNGEIWELS----RCSRNKRENTSSLGYEYT---------GSKKE 122

  Fly    99 TKTCSSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFA 163
            ......|:||::.:.::|||:|||||.|..|:.....|||.||||||:.||..||:|||:...:|
Human   123 FPCVDGYIYDQNTWKSTAVTQWNLVCDRKWLAMLIQPLFMFGVLLGSVTFGYFSDRLGRRVVLWA 187

  Fly   164 SLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSV 228
            :.....:||:.||.|.:|:::..:|..:....||..:|.:|..:|.:|...|.:|.|.:..||:|
Human   188 TSSSMFLFGIAAAFAVDYYTFMAARFFLAMVASGYLVVGFVYVMEFIGMKSRTWASVHLHSFFAV 252

  Fly   229 GFMLTAGFAYFIHDWRWL-QIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENK 292
            |.:|.|...|.:..| || |:.::...:.|:...|::||:..|||.:||.:||..|::..||.|:
Human   253 GTLLVALTGYLVRTW-WLYQMILSTVTVPFILCCWVLPETPFWLLSEGRYEEAQKIVDIMAKWNR 316

  Fly   293 VEVPNEIYEQLVDEVAEKKKQDEM--------AASQPAATVFDLLRYP----NLRRKTLLIFFDW 345
                           |...|..|:        .::.|.......|.|.    ::.::||.::..|
Human   317 ---------------ASSCKLSELLSLDLQGPVSNSPTEVQKHNLSYLFYNWSITKRTLTVWLIW 366

  Fly   346 FVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLA 410
            |..|..:|..|.|:.|||||:.:|..:.|.||||.||.:...:::.|||::|..::..:.::...
Human   367 FTGSLGFYSFSLNSVNLGGNEYLNLFLLGVVEIPAYTFVCIAMDKVGRRTVLAYSLFCSALACGV 431

  Fly   411 TIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLK 475
            .:.:|.....|.|..||:||.||.:::|.||:::||.:||:||::.:|:.|||.|:..||||:..
Human   432 VMVIPQKHYILGVVTAMVGKFAIGAAFGLIYLYTAELYPTIVRSLAVGSGSMVCRLASILAPFSV 496

  Fly   476 LLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIE-----DGENFGKKPAPQETAEEGG 535
            .|..||..:|.:..|.::|.:|:|:|.|||||.|.:..|.|     :.||..|......|....|
Human   497 DLSSIWIFIPQLFVGTMALLSGVLTLKLPETLGKRLATTWEEAAKLESENESKSSKLLLTTNNSG 561

  Fly   536 TQELSGMLNGKSG 548
            .::...:....||
Human   562 LEKTEAITPRDSG 574

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_524479.1	2A0119	11..514	CDD:273328	173/549 (32%)
SLC22A16	NP_149116.2	MFS_SLC22A16_CT2	118..525	CDD:340933	141/422 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	543..577		7/32 (22%)