Protein Alignment Orct and TPO2

DIOPT Version :10

• Sequence 1: NP_524479.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_011654.1
• Gene: TPO2 / 853039
• SGDID: S000003370
• Length: 614
• Species: Saccharomyces cerevisiae
• Alignment Length: 536
• Identity: 107/536 - (19%)
• Similarity: 181/536 - (33%)
• Gaps: 188/536 - (35%)

  Fly    67 NLSYPENERCSYYDVDYTEEYLNGSIPRSSNET--KTCSSYVYDRSKYLNSAVT----------- 118
            :::.|:..:.:.:..:||.|..:|.:|.::.::  :|.|:....|:|.||...|
Yeast    64 DINAPQTAKNNIFPEEYTMETPSGLVPVATLQSMGRTASALSRTRTKQLNRTATNSSSTGKEEME 128

  Fly   119 ----------------------------------------EWNLVCSRSLL-------------- 129
                                                    .|:.....|:|
Yeast   129 EEETEEREDQSGENELDPEIEFVTFVTGDPENPHNWPSWVRWSYTVLLSILVICVAYGSACISGG 193

  Fly   130 --------------SATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPE 180
                          :..|.||.::|..||.||:..:||..||:..:|.|:.|.:||.:..|:||.
Yeast   194 LGTVEKKYHVGMEAAILSCSLMVIGFSLGPLIWSPVSDLYGRRVAYFVSMGLYVIFNIPCALAPN 258

  Fly   181 YFSYTISRMIVGA-TTSGVFLVAYVIA----LEMVGSSYRLFA---------GVAMQMFFSVGFM 231
            .......|.:.|. ::||:.||...||    .|..|.:...||         |..:..|.||
Yeast   259 LGCLLACRFLCGVWSSSGLCLVGGSIADMFPSETRGKAIAFFAFAPYVGPVVGPLVNGFISV--- 320

  Fly   232 LTAGFAYFIHDWRWLQIAITLPGLLFLCYYWI----IPESARWLLMKGRKDEAFVIIEKAAKENK 292
             :.|....|.   |:.:|       |....||    |||:...:::|          .|||:..|
Yeast   321 -STGRMDLIF---WVNMA-------FAGVMWIISSAIPETYAPVILK----------RKAARLRK 364

  Fly   293 VEVPNEIYEQLVDEVAEKKKQDEM-----------AASQP--AATVFDLLRYPNLRRKTLLIFFD 344
             |..|.  :.:.::.|:.....||           |.::|  .||.|    |..|....|..||.
Yeast   365 -ETGNP--KIMTEQEAQGVSMSEMMRACLLRPLYFAVTEPVLVATCF----YVCLIYSLLYAFFF 422

  Fly   345 WF-VNSGVYYGLSWNTNNLGGNQLVNFMIS-------------------------------GA-V 376
            .| |..|..||..   :||.|...:..:|.                               || :
Yeast   423 AFPVIFGELYGYK---DNLVGLMFIPIVIGALWALATTFYCENKYLQIVKQRKPTPEDRLLGAKI 484

  Fly   377 EIPGYTLLLFTLNRWGRRSILCGTMMVAGISL-LATIFVPSDMNWLIVAC-------AMIGKLAI 433
            ..|...:.|:.|.....:.|:......||::. ...:.:...:|..|:.|       |:..|:.:
Yeast   485 GAPFAAIALWILGATAYKHIIWVGPASAGLAFGFGMVLIYYSLNNYIIDCYVQYASSALATKVFL 549

  Fly   434 TSSYGTIY-IFSAEQF 448
            .|:.|..: :|:.:.:
Yeast   550 RSAGGAAFPLFTIQMY 565

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_524479.1	2A0119	11..514	CDD:273328	107/536 (20%)
TPO2	NP_011654.1	MFS_Tpo1_MDR_like	173..599	CDD:340881	93/427 (22%)