DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and Slc22a8

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_112622.1	Gene:	Slc22a8 / 83500	RGDID:	632286	Length:	536	Species:	Rattus norvegicus

Alignment Length:	553	Identity:	176/553 - (31%)
Similarity:	295/553 - (53%)	Gaps:	23/553 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL 65
            |.:.:::..:|..||:|.....||.||.:..|.|.|..:|....|...|. |..|.||   .|
  Rat     1 MTFSEILDRVGSMGPFQYLHVTLLALPVLGIANHNLLQIFTATTPVHHCR-PPPNASI---GP-- 59

  Fly    66 WNLSYPEN---ERCSYYDVDYTEEYLNGSIPRSSNE-TKTC-SSYVYDRSKYLNSAVTEWNLVCS 125
            |.|....|   |:|..:     ....|.|:|..:.. |:.| ..::|:.::  ::.|.||:||||
  Rat    60 WVLPLDPNGKPEKCLRF-----VHLPNASLPNDTQRATEPCLDGWIYNSTR--DTIVIEWDLVCS 117

  Fly   126 RSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMI 190
            .:.|...:.|:||.|:|:|..:.|::||:.||||....|.::....|..||.:|....|.|.|.:
  Rat   118 SNKLKEMAQSIFMAGILVGGPVIGELSDRFGRKPILTWSYLMLAASGSGAAFSPSLPVYMIFRFL 182

  Fly   191 VGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGL 255
            .|.:.||:.|...::.:|.|.:|.|..:..::...:::|..:.:|.||.|..|||||:..:.|..
  Rat   183 CGCSISGISLSTVILNVEWVPTSMRAISSTSIGYCYTIGQFILSGLAYAIPQWRWLQLTSSAPFF 247

  Fly   256 LFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQ 320
            :|....|.:|||.|||::.|:..:|...:::.|..|.   ..|..::|..|..:...|.::.:::
  Rat   248 IFSLLSWWVPESIRWLVLSGKYSKALKTLQRVATFNG---KKEEGKKLTIEELKFNLQKDITSAK 309

  Fly   321 PAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLL 385
            ....:.||.|...|||.|..:...||.....||.|:......|.|..:..:|.|.|:||...:.:
  Rat   310 VKYGLSDLFRVSILRRVTFCLSLAWFSTGFAYYSLAMGVEEFGVNIYILQIIFGGVDIPAKFITI 374

  Fly   386 FTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPT 450
            .:|:..|||......:::||.::||.|||||:|..|..|.|:.||..::.|:..::::::|.:||
  Rat   375 LSLSYLGRRITQSFLLLLAGGAILALIFVPSEMQLLRTALAVFGKGCLSGSFSCLFLYTSELYPT 439

  Fly   451 VVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETI 515
            |:|..|:|.|::.||||.::||.:|:.||:...:|.:|.|..:|..|..:..|.||||:|:||||
  Rat   440 VLRQTGMGISNVWARVGSMIAPLVKITGELQPFIPNVIFGTTALLGGSAAFFLLETLNRPLPETI 504

  Fly   516 EDGENFGKKPAPQETAEEGGTQELSGMLNGKSG 548
            ||.:|:.|:  .|:|.:|...::.|.::..|:|
  Rat   505 EDIQNWHKQ--VQKTKQESEAEKASQIIPLKTG 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	162/507 (32%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	114/355 (32%)
Slc22a8	NP_112622.1	2A0119	11..503	CDD:273328	162/507 (32%)
		MFS	124..492	CDD:119392	117/370 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	515..536		6/21 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347117
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.950