Protein Alignment Orct and Sv2c

DIOPT Version :9

• Sequence 1: NP_001262908.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_083486.1
• Gene: Sv2c / 75209
• MGIID: 1922459
• Length: 727
• Species: Mus musculus
• Alignment Length: 566
• Identity: 116/566 - (20%)
• Similarity: 201/566 - (35%)
• Gaps: 192/566 - (33%)

  Fly   113 LNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAV 177
            |.||.|:   :|..:..|....|:..||:::|:..:|.::||:|||.:....:.:...|..|::.
Mouse   176 LPSAETD---LCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSF 237

  Fly   178 APEYFSYTISRMI----VGATTSGVF-LVAYVIALE-------------MVGSSYRLFAGVAMQM 224
            ...|..:.:.|::    :|.....|| ..|.|:|.|             |:|..|.  :.:|..:
Mouse   238 VQGYGFFLVCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYA--SAMAWAI 300

  Fly   225 FFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVII----- 284
            ....|:..:.|.||..|.||...|...||.:..:.....:|||.|:||..|:.|||::|:
Mouse   301 IPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHD 365

  Fly   285 ---------EKAAKENKVEVPNEIYEQLVDEVAEKKK-------------QDEMAASQPAATVFD 327
                     ||....||::.|.:|     ||:.|.:.             :.|:....  .|...
Mouse   366 TNMRARGQPEKVFTVNKIKTPKQI-----DELIEIESDTGTWYRRCFVRIRTELYGIW--LTFMR 423

  Fly   328 LLRYPNLRRKTLLIFFDWFVNSGVYYGLS-W---------------NTNNLGGNQLVNFMISGAV 376
            ...|| :|..|:.:...||..|..||||| |               .|.|:..::..||.|:..:
Mouse   424 CFNYP-VRENTIKLTIVWFTLSFGYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTM 487

  Fly   377 E---------------------------------------------------------------- 377
            |
Mouse   488 ENQIHTGMEYENGRFLGVKFKSVTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFDNTDFEPYKF 552

  Fly   378 -----------------------------------------IPGYTLLLFTLNRWGRRSILCGTM 401
                                                     :||..:....::|.||.::|.|:|
Mouse   553 IDSEFQNCSFLHNKTGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSM 617

  Fly   402 MVAGISLLATIFVPSDMNWLIVACAMIGKLAI-----TSSYGTIYIFSAEQFPTVVRNVGLGASS 461
            :::|||.....|..|:       ..|||.|.:     .|::.::.:.:.|.:||..|..|.|..:
Mouse   618 VLSGISCFFLWFGTSE-------SMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLN 675

  Fly   462 MVARVGGILAPYL-KLLGEIWRPLPLIICGALSLTAGLLSLLLPET 506
            .:.:...:|...: ..|..|.:.:|:::...:.:..||:.|.||:|
Mouse   676 ALCKAAAVLGNLIFGSLVSITKAIPILLASTVLVCGGLVGLRLPDT 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	116/566 (20%)
		MFS	135..491	CDD:119392	104/527 (20%)
Sv2c	NP_083486.1	synapt_SV2	1..727	CDD:130366	116/566 (20%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	22..128

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940