DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and slc22a15.2

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001039179.1	Gene:	slc22a15.2 / 734018	XenbaseID:	XB-GENE-5824718	Length:	487	Species:	Xenopus tropicalis

Alignment Length:	532	Identity:	176/532 - (33%)
Similarity:	278/532 - (52%)	Gaps:	61/532 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL 65
            |..|:...::||||..|||:...|.|..:..|...:..|.:.|.|::..
Frog     1 MDLDEAFLYIGEFGCCQKRLTAFLTLLQVYVACQSMLIVLVGAVPEYLI---------------- 49

  Fly    66 WNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCSRSLLS 130
                  :||..|....:||:                   :::|.:.: .|.|:||:|:.:.:...
Frog    50 ------DNEDISASKEEYTK-------------------HLHDTNNF-TSIVSEWHLIKNEAYKV 88

  Fly   131 ATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATT 195
            ..:.|||..|:|:|:::||.:||||||:|.:.:.|...:.||...|:||.|..:.:||..||...
Frog    89 NLASSLFFAGLLIGNILFGPLSDKLGRRPVYLSGLFFDITFGYCTALAPSYEVFAVSRFFVGIMN 153

  Fly   196 SGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCY 260
            .|:.||::|:..|.||.||....|....:.|:||....|...::|.:||.|......||:.|...
Frog   154 GGMALVSFVLTQEYVGKSYWALTGSLTNLIFAVGIAFYALLGFYIRNWRTLAFVANSPGIFFFLL 218

  Fly   261 YWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPAATV 325
            .:::|||.|||...|...||..:::..|..|.||.|           ..|.|.....:|:.|.:|
Frog   219 SFLLPESPRWLYSHGYTTEAEGVLQSMAVGNGVERP-----------VVKLKSCPGTSSKSAHSV 272

  Fly   326 FDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNR 390
            |||::|..||.:|:|:.:.|:|.|.|||||:.|...|.||..:|..:.|.||:|.:.|.|:.:.:
Frog   273 FDLVKYGVLRWRTILLMYIWYVCSLVYYGLTLNAGELKGNLYLNVALYGLVEVPAFPLCLYFIEK 337

  Fly   391 -W-GRRSILCGTMMVAGISLLATIFVPSDMNWLI--VACAMIGKLAITSSYGTIYIFSAEQFPTV 451
             | |||....|.:..||.:.:.|||:|.....|:  ...|:.|||::::::..:||:::|.:|||
Frog   338 SWSGRRKATAGFLGFAGFACIFTIFLPETNGDLLNPTVLALFGKLSVSAAFNVVYIYTSELYPTV 402

  Fly   452 VRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIE 516
            |||.|||..:|..|.||||:|::..:..:...:|.:..|...::||:||||||||.|||:.|:||
Frog   403 VRNAGLGVCAMACRFGGILSPFIPTMKSLNPSMPFVAFGISGISAGILSLLLPETRNKPIAESIE 467

  Fly   517 DGENFGKKPAPQ 528
            |.::    ||.|
Frog   468 DLQS----PAYQ 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	167/506 (33%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	129/359 (36%)
slc22a15.2	NP_001039179.1	MFS	48..455	CDD:391944	147/459 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920