Protein Alignment Orct and SLC22A5

DIOPT Version :10

• Sequence 1: NP_524479.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_001295051.1
• Gene: SLC22A5 / 6584
• HGNCID: 10969
• Length: 581
• Species: Homo sapiens
• Alignment Length: 588
• Identity: 198/588 - (33%)
• Similarity: 304/588 - (51%)
• Gaps: 78/588 - (13%)

  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHLWN 67
            ||:|...|||:||:|:.|::||....|...|..|:.|||:|.|:.||.:|    ....||....|
Human     4 YDEVTAFLGEWGPFQRLIFFLLSASIIPNGFTGLSSVFLIATPEHRCRVP----DAANLSSAWRN 64

  Fly    68 LSYPENER--------CSYY-----------------DVDYTEEYLNGSIPRSSNETKTC-SSYV 106
            .:.|...|        |..|                 |||.      |.:     |.::| ..:.
Human    65 HTVPLRLRDGREVPHSCRRYRLATIANFSALGLEPGRDVDL------GQL-----EQESCLDGWE 118

  Fly   107 YDRSKYLNSAVTE------------------------WNLVCSRSLLSATSDSLFMLGVLLGSLI 147
            :.:..||::.|||                        |||||.....:..:.|||.:||||||.|
Human   119 FSQDVYLSTIVTEQDSGAYNAMKNRMGKKPALCLPAQWNLVCEDDWKAPLTISLFFVGVLLGSFI 183

  Fly   148 FGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGS 212
            .||:||:.|||...|.::.:|..|..|...:..:..:.:..::||......::.|:|:..|::|.
Human   184 SGQLSDRFGRKNVLFVTMGMQTGFSFLQIFSKNFEMFVVLFVLVGMGQISNYVAAFVLGTEILGK 248

  Fly   213 SYR-LFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGR 276
            |.| :|:.:.:.:|::.|:|:...|||||.|||.|.:|:|:||:|.:..:|.||||.|||:.:||
Human   249 SVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGR 313

  Fly   277 KDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLI 341
            .:||.|||.||||.|.:.||:.|::       ..:.||..:..|.:..:.||||..|:|..|::.
Human   314 FEEAEVIIRKAAKANGIVVPSTIFD-------PSELQDLSSKKQQSHNILDLLRTWNIRMVTIMS 371

  Fly   342 FFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGI 406
            ...|...|..|:|||.:|.||.|:..||..:|..||:|.|.|....|....||..:...:.:.|.
Human   372 IMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGS 436

  Fly   407 SLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILA 471
            .||....||.|:.:|.....|:||..:|:::..:|:::||.:||||||:|:|.||..:|:|.||:
Human   437 VLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILS 501

  Fly   472 PYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIED-----GENFGKKPAPQETA 531
            ||...||...|.||.|:.|:|::...:|:|.|||:...|:|:||:.     |....|.|:.....
Human   502 PYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDTIDQMLRVKGMKHRKTPSHTRML 566

  Fly   532 EEG 534
            ::|
Human   567 KDG 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_524479.1	2A0119	11..514	CDD:273328	188/553 (34%)
SLC22A5	NP_001295051.1	2A0119	12..544	CDD:273328	188/553 (34%)