Protein Alignment Orct and SLC22A3

DIOPT Version :9

• Sequence 1: NP_001262908.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 556
• Identity: 187/556 - (33%)
• Similarity: 291/556 - (52%)
• Gaps: 59/556 - (10%)

  Fly     3 YDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDF-------------RCA-LPY 53
            :|:.:..:||||.:|:|::.||||..:..||..:..|||..:||.             ||. .|.
Human     4 FDEALQRVGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGTQPDHYWCRGPSAAALAERCGWSPE 68

  Fly    54 ENGSIYELSPHLWNLSYPENE---------RCSYYDVDYTEEYLN-----------GSIPRSSNE 98
            |.          ||.:.|.:.         ||..|.::...:..:           .:.|..|..
Human    69 EE----------WNRTAPASRGPEPPERRGRCQRYLLEAANDSASATSALSCADPLAAFPNRSAP 123

  Fly    99 TKTC-SSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFF 162
            ...| ..:.|.::.  ::.|:|::|||..:.:...:.::..||.|.|:...|..:|:.||...:.
Human   124 LVPCRGGWRYAQAH--STIVSEFDLVCVNAWMLDLTQAILNLGFLTGAFTLGYAADRYGRIVIYL 186

  Fly   163 ASLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFS 227
            .|.:...:.||:.|.||.:..:.|.|.:.|....|.::..|||..|:|||..|...|:.:||||:
Human   187 LSCLGVGVTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFT 251

  Fly   228 VGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENK 292
            :|.::..|.||||.:|:.:|:|||||..|||.|||::|||.|||:.:.:.|:|..|:.:.||.|.
Human   252 LGIIILPGIAYFIPNWQGIQLAITLPSFLFLLYYWVVPESPRWLITRKKGDKALQILRRIAKCNG 316

  Fly   293 VEVPNEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSW 357
                    :.|....:|....|| ..|.|  :..||:|.|.:|:.||::.|.||.::.||.||..
Human   317 --------KYLSSNYSEITVTDE-EVSNP--SFLDLVRTPQMRKCTLILMFAWFTSAVVYQGLVM 370

  Fly   358 NTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLI 422
            ....:|||..::|.|||.||:||..|:|.|:.|.|||.....:.:|||::.|.|.|:|..:.||.
Human   371 RLGIIGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLR 435

  Fly   423 VACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKL-LGEIWRPLPL 486
            ...|.:|:|.||.::..:|:.::|.:||.:||.|:...|.:...|||:||:|.. |..:|..|||
Human   436 TTVATLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELPL 500

  Fly   487 IICGALSLTAGLLSLLLPETLNKPMPETIEDGENFG 522
            ||.|.|:...|.|.:|||||....:|||::|.|..|
Human   501 IIFGILASICGGLVMLLPETKGIALPETVDDVEKLG 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	181/538 (34%)
		MFS	135..491	CDD:119392	135/356 (38%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	181/538 (34%)
		MFS	149..518	CDD:119392	140/379 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153530
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9N9
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.850