Protein Alignment Orct and SLC22A1

DIOPT Version :9

• Sequence 1: NP_001262908.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: XP_005267159.1
• Gene: SLC22A1 / 6580
• HGNCID: 10963
• Length: 610
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 172/509 - (33%)
• Similarity: 267/509 - (52%)
• Gaps: 39/509 - (7%)

  Fly     4 DDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL-WN 67
            ||::..:||.|.:||:.:.:|||.:...|...:..|||...||..|..|    .:.|||... |:
Human     5 DDILEQVGESGWFQKQAFLILCLLSAAFAPICVGIVFLGFTPDHHCQSP----GVAELSQRCGWS 65

  Fly    68 ----LSY------PENE----RCSYYDVDYTEEYLNGSIPRSSNETK-------TC-SSYVYDRS 110
                |:|      |..|    :|..|:||:.:..|:...|.:|..|.       .| ..:|||..
Human    66 PAEELNYTVPGLGPAGEAFLGQCRRYEVDWNQSALSCVDPLASLATNRSHLPLGPCQDGWVYDTP 130

  Fly   111 KYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLA 175
            .  :|.|||:||||:.|.......|....|.|.|||..|..:|:.|||.....::::..:.|||.
Human   131 G--SSIVTEFNLVCADSWKLDLFQSCLNAGFLFGSLGVGYFADRFGRKLCLLGTVLVNAVSGVLM 193

  Fly   176 AVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFI 240
            |.:|.|.|..:.|::.|..:.|.::..|.:..|.|||..|....:..||.|:||.:...|.||.:
Human   194 AFSPNYMSMLLFRLLQGLVSKGNWMAGYTLITEFVGSGSRRTVAIMYQMAFTVGLVALTGLAYAL 258

  Fly   241 HDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVD 305
            ..|||||:|::||..|||.|||.:|||.||||.:.|..||..|::..|::|....|.::....::
Human   259 PHWRWLQLAVSLPTFLFLLYYWCVPESPRWLLSQKRNTEAIKIMDHIAQKNGKLPPADLKMLSLE 323

  Fly   306 EVAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNF 370
            |...:|.....|         ||.|.|.||::|.::.:.||.:|.:|.||..:.....||..::|
Human   324 EDVTEKLSPSFA---------DLFRTPRLRKRTFILMYLWFTDSVLYQGLILHMGATSGNLYLDF 379

  Fly   371 MISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITS 435
            :.|..|||||..:.|.|::|.||...:..:.::||.:.|..||:..|::||.:....:|::.||.
Human   380 LYSALVEIPGAFIALITIDRVGRIYPMAMSNLLAGAACLVMIFISPDLHWLNIIIMCVGRMGITI 444

  Fly   436 SYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKL-LGEIWRPLPLII 488
            :...|.:.:||.:||.|||:|:...|.:..:|||:.|::.. |.|:|:.||||:
Human   445 AIQMICLVNAELYPTFVRNLGVMVCSSLCDIGGIITPFIVFRLREVWQALPLIL 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	170/502 (34%)
		MFS	135..491	CDD:119392	125/355 (35%)
SLC22A1	XP_005267159.1	2A0119	12..499	CDD:273328	170/502 (34%)
		MFS	118..484	CDD:119392	131/376 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.950