DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and Sv2a

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_071313.1	Gene:	Sv2a / 64051	MGIID:	1927139	Length:	742	Species:	Mus musculus

Alignment Length:	546	Identity:	100/546 - (18%)
Similarity:	190/546 - (34%)	Gaps:	181/546 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 SDS-------LFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMI 190
            |||       :..||:::|:.::|.::|:|||:.....||.:..:|...::....|.::...|::
Mouse   200 SDSNKGMLGLIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLL 264

  Fly   191 VGATTSGVFLVAY-----VIALE-------------MVGSSYRLFAGVAMQMFFSVGFMLTAGFA 237
            .|....|...:.:     .:|.|             |:|..|.  |.:|..:....|:....|.|
Mouse   265 SGVGIGGSIPIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYA--AAMAWAIIPHYGWSFQMGSA 327

  Fly   238 YFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEV--PNEIY 300
            |..|.||...:....|.:..:......|||.|:.|..|:.|||::::::....|....  |..::
Mouse   328 YQFHSWRVFVLVCAFPSVFAIGALTTQPESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVF 392

  Fly   301 EQLVDEVAEKKKQDEMAASQ-PAATVFDLLRY--------------------PNLRRKTLLIFFD 344
            .  |..:....::||:...| ...|.:.  |:                    |..||.||::...
Mouse   393 S--VTHIKTIHQEDELIEIQSDTGTWYQ--RWGVRALSLGGQVWGNFLSCFSPEYRRITLMMMGV 453

  Fly   345 WFVNSGVYYGLS-W-----------------------------------NTNNLGG--------- 364
            ||..|..||||: |                                   |..:.||
Mouse   454 WFTMSFSYYGLTVWFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIG 518

  Fly   365 --------------------------------------------------NQLVN--FM------ 371
                                                              ::|||  |:
Mouse   519 LRLKSVSFEDSLFEECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEGC 583

  Fly   372 ---ISGAVE----------------IPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSD 417
               ::|..|                :||..:....:::.||..:|.|:.:::.:|.....|..|:
Mouse   584 PLDVTGTGEGAYMVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVLSCVSCFFLSFGNSE 648

  Fly   418 MNWLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGIL--APYLKLLGEI 480
            ...:.:.| :.|.::| :|:..:.:.:.|.:|:..|....|..:.:.::..:|  :.:...:| |
Mouse   649 SAMIALLC-LFGGVSI-ASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVG-I 710

  Fly   481 WRPLPLIICGALSLTAGLLSLLLPET 506
            .:..|::...|.......|:|.||||
Mouse   711 TKAAPILFASAALALGSSLALKLPET 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	100/546 (18%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	91/527 (17%)
Sv2a	NP_071313.1	synapt_SV2	1..742	CDD:130366	100/546 (18%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..145
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940