Protein Alignment Orct and SLC22A11

DIOPT Version :9

• Sequence 1: NP_001262908.1
• Gene: Orct / 42891
• FlyBaseID: FBgn0019952
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_060954.1
• Gene: SLC22A11 / 55867
• HGNCID: 18120
• Length: 550
• Species: Homo sapiens
• Alignment Length: 571
• Identity: 172/571 - (30%)
• Similarity: 269/571 - (47%)
• Gaps: 63/571 - (11%)

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRC-ALPYENGSIYELS-- 62
            |.:..::...|..|.:|........||.::.....|...|..|.|..|| ....:|||....:
Human     1 MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAVSTNMT 65

  Fly    63 ----------------PH--------LWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCS 103
                            ||        .|.|..|.....|:.:.| ||..::|
Human    66 PKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEAD-TEPCVDG------------- 116

  Fly   104 SYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQ 168
             :|||||.:.::.|.:|:||||...|...|.|:||.|:|:||.|:|.:|.:.|||| ..:...||
Human   117 -WVYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKP-MLSWCCLQ 179

  Fly   169 L-IFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFML 232
            | :.|.....||.:..|...|.:.....:|:||.:..:.:|...:|.|......:...||.|...
Human   180 LAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCAFSAGQAA 244

  Fly   233 TAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKEN-KVEVP 296
            ..|.|:.:.|||.||:|.::|........|.:|||||||::||:.|:|...:.|.|:.| ..|..
Human   245 LGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELRKVARINGHKEAK 309

  Fly   297 NEIYEQLVDEVAEKKKQDEMAASQPAATVFDLLRYPNLRRKT---LLIFFDWFVNSGVYYGLSWN 358
            |...|.|:..|.|     |:|:::...:|.||...|.||.::   |::.|...::   ||||.::
Human   310 NLTIEVLMSSVKE-----EVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSLLIS---YYGLVFD 366

  Fly   359 TNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIV 423
            ..:||.:..:...:.|||:..|.......|:..|||:|..|:..:||:::||.:.||.|:..|.|
Human   367 LQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAILANMLVPQDLQTLRV 431

  Fly   424 ACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLII 488
            ..|::||.....|...:.|:.||.|||.||....|....|.|:|.::.|.:.:..:....||.::
Human   432 VFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGAMMGPLILMSRQALPLLPPLL 496

  Fly   489 CGALSLTAGLLSL-LLPETLNKPMPETIEDGENFGKKPAPQETAEEGGTQE 538
            .|.:|:.:.|:.| .||||...|:|:||:|.|      :.:.||.:|..||
Human   497 YGVISIASSLVVLFFLPETQGLPLPDTIQDLE------SQKSTAAQGNRQE 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	162/535 (30%)
		MFS	135..491	CDD:119392	115/360 (32%)
SLC22A11	NP_060954.1	Sugar_tr	11..523	CDD:331684	162/535 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	531..550		5/11 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153210
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.950