DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and slc22a16

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001020659.1	Gene:	slc22a16 / 557279	ZFINID:	ZDB-GENE-041001-166	Length:	565	Species:	Danio rerio

Alignment Length:	564	Identity:	180/564 - (31%)
Similarity:	287/564 - (50%)	Gaps:	50/564 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 GYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALP-------YEN---- 55
            |.:.:...||.|..:|..:|:.....||.|..|.||.|||:..|.|.|..|       |:|
Zfish     4 GVERLFDELGHFKRFQACLYFAAIFQAISCGIHYLASVFLVETPKFLCNPPLNITDVLYKNLSFT 68

  Fly    56 ----------------------GSIYELSPHLWNLSYPENERCSYYDVDYTEEYLNGSIPRSSNE 98
                                  |..:||||.|..|      |....:..| |.:.|.|:
Zfish    69 SLADIWTHYKTGDGPVVVRTSQGDQWELSPCLKAL------RLDAINFQY-EFFGNKSV------ 120

  Fly    99 TKTCSSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFA 163
             ::|.::|||.|:...|.||:|:|||.|..|:..:...||||||:|:|:||..:|::||:|...|
Zfish   121 -ESCGAFVYDHSEVEQSIVTDWDLVCEREWLAKLTQPTFMLGVLIGALMFGDAADRIGRRPVLMA 184

  Fly   164 SLVLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSV 228
            :.:.|.||||..|....|:.:.:.|.::...:||..:|.:|...|..|...|.:..:.:...|:|
Zfish   185 TSLCQFIFGVTVAFTGNYYLFVVMRFLLATVSSGYLVVVFVYVTEFTGIKVRTWTSMHVHAAFAV 249

  Fly   229 GFMLTAGFAYFIHDWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKV 293
            |.|:.|...|.:..|...||.:||....||.|.|..||:..:|:.|||..||..:::..|..|.:
Zfish   250 GIMVVALVGYLVRVWWIYQIILTLSTSPFLLYCWKFPETPFYLMAKGRYKEAQELLDTMAYINGL 314

  Fly   294 EVPNEIYEQLVDEVAEKKKQDEMAAS--QPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLS 356
            . |......|.|.......:|...|.  :...::.|:.....:..::...:..||:.|..||..|
Zfish   315 P-PTLKVSDLQDGCDRTPLKDNKQAMEVEKRLSMLDMFGSLKMAGRSATCWAIWFIGSLGYYVFS 378

  Fly   357 WNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWL 421
            ..:.||||||.:|..::||||:|.|.:..|.::|:||:......:::.|::.:..|.||.|:..|
Zfish   379 LGSVNLGGNQYINLFLAGAVEVPSYLIGCFAMDRFGRKKTCAPALLLGGVACMLIIVVPQDVEVL 443

  Fly   422 IVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPL 486
            .:..:|.||.||..::|.||:::.|.:||::|::.:|:.||:.|||.::||:...|.:||..||.
Zfish   444 AIVLSMTGKFAIAIAFGLIYLYTCELYPTIIRSLAVGSGSMMCRVGSVVAPFCVYLADIWIYLPQ 508

  Fly   487 IICGALSLTAGLLSLLLPETLNKPMPETIEDGENFGKKPAPQET 530
            :|.|.|:...|:|::.|||||.:|:..|:|:.|..|.||..:.|
Zfish   509 LIVGILAFIIGILTMFLPETLGEPLTSTLEEAEALGSKPNTKNT 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	171/537 (32%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	116/357 (32%)
slc22a16	NP_001020659.1	2A0119	13..536	CDD:273328	171/537 (32%)
slc22a16	NP_001020659.1	MFS	158..526	CDD:119392	120/368 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588669
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.880