DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and slc22a15

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001103169.1	Gene:	slc22a15 / 555262	ZFINID:	ZDB-GENE-070928-5	Length:	497	Species:	Danio rerio

Alignment Length:	520	Identity:	168/520 - (32%)
Similarity:	271/520 - (52%)	Gaps:	57/520 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL 65
            |..::....:||||.:|||:..:|....|..|...:..:.:.|.|:
Zfish     1 MDLEEAFQVVGEFGSHQKRMITVLVFLQIYMACQSMLIILVGAVPE------------------- 46

  Fly    66 WNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCSRSLLS 130
                         |.::...|.::|.:.:|...|:.           :||.||||.||..::...
Zfish    47 -------------YHIEPVTEGVDGDVTQSVKFTED-----------VNSIVTEWYLVKHQAYKV 87

  Fly   131 ATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATT 195
            ..:.|||..|||:|:::||.:|||:||||.|...|..:::||...|:||.|.::.:||::||...
Zfish    88 NLAGSLFFAGVLIGNVVFGPLSDKIGRKPVFLTGLFFEVLFGYGTALAPSYEAFAVSRLLVGVMN 152

  Fly   196 SGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCY 260
            .|:.||.:|:..|.||.||....|....|.|:||..|.|...|::..||.|..|...||||....
Zfish   153 GGMALVCFVLTQEYVGKSYWAMTGTLTNMTFAVGISLFAALGYYVRPWRNLATAANCPGLLLFLL 217

  Fly   261 YWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPAATV 325
            ...:|||.|||..:|..::|..|::..|..|.           ...:..|.::...:.:..:..|
Zfish   218 CVTLPESPRWLYSRGYTEKAEDILQDFALRNG-----------KGRIVVKLRRASSSPNSSSPGV 271

  Fly   326 FDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLFTLNR 390
            |.|:.:|.||.:|:::.:.|:..|.|||||:.|.....||:.::..:.|.||:|.|.|.::.:|:
Zfish   272 FQLVTHPVLRWRTVVLMYVWYACSLVYYGLTLNAGEDKGNRYLSVAMYGLVELPAYPLCMYFINK 336

  Fly   391 -W-GRRSILCGTMMVAGISLLATIFVPSDMNWL-IVACAMIGKLAITSSYGTIYIFSAEQFPTVV 452
             | |||..:...:..||||.|.|:.||...:.| ..:.|::|||.:::::..:|::::|.:|||:
Zfish   337 PWAGRRKSMANFLAFAGISCLLTMVVPVSGSLLSATSLALVGKLMVSAAFNIVYVYTSELYPTVI 401

  Fly   453 RNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIED 517
            ||.|||..||..||||||||::..:..:...:|.::.....::||.|.||||||||||..||:::
Zfish   402 RNAGLGVCSMSCRVGGILAPFVPSMKSLHTSMPFMVFCLSGISAGCLGLLLPETLNKPAAETLDE 466

Fly 518 517
Zfish 467 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	165/505 (33%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	127/358 (35%)
slc22a15	NP_001103169.1	2A0119	11..463	CDD:273328	165/505 (33%)
slc22a15	NP_001103169.1	MFS	87..453	CDD:119392	132/376 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588753
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850