DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and oatx

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_017208528.1	Gene:	oatx / 555218	ZFINID:	ZDB-GENE-070115-1	Length:	567	Species:	Danio rerio

Alignment Length:	555	Identity:	190/555 - (34%)
Similarity:	303/555 - (54%)	Gaps:	22/555 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL 65
            ||:.|::..:|.||.:|.....||.:|.::.|...|...|....|:..|.:|....::.:.:..|
Zfish     1 MGFADLLDEVGGFGRFQMIHVTLLSIPGLLMASQNLLNNFTAGVPEHHCRIPNVTTAMNDSTTTL 65

  Fly    66 WNLSYPEN-----ERCS-YYDVDY---TEEYLNGSIPRSSNETKTCS-SYVYDRSKYLNSAVTEW 120
            .....|.:     .:|| |.|..:   |::..:|:  .:..:|:.|: .:.||:|::::|.|:||
Zfish    66 LRAFIPLDSSLTLSKCSRYKDTQWHLITDKLSHGN--ATELQTEGCADGWTYDKSEFISSIVSEW 128

  Fly   121 NLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYT 185
            :|||:...|...|.:::|.|||.|::|||.:||:.|||.....|.....:.|...|:||.|..|.
Zfish   129 DLVCTLRPLKQMSQTIYMGGVLTGAIIFGGLSDRFGRKALLIWSYFQLALLGSFTALAPSYVVYC 193

  Fly   186 ISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAI 250
            |.|.:.|.:.|||.|.|..:.:|.:.:..|...|.....||:.|.|:.||.||.:.|||.:|:|:
Zfish   194 IFRFLTGMSVSGVILNAVSLKVEWIPTKTRTLVGTLSSFFFTFGQMVLAGVAYSLRDWRKIQMAV 258

  Fly   251 TLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDE 315
            .||..:|..|.|...||||||::.||.:||..::.:.||.|.   ..|:.|::..|..|...|.|
Zfish   259 CLPFFIFFMYSWWFSESARWLVLNGRSEEALKLLHRVAKING---KPEMTEKITLEELESHMQKE 320

  Fly   316 MAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPG 380
            :.:|:...|||||||.|.:|:.::.:...||..|..||||:.:....|.|..:..:|.|||:.|.
Zfish   321 VQSSKSIYTVFDLLRTPTMRKISMCLMVVWFSTSFAYYGLAMDLQKFGVNIYLMQVIFGAVDFPA 385

  Fly   381 YTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWLIVACAMIGKLAITSSYGTIYIFSA 445
            ..:.|..|:..|||......::|:...:.|.||||.||.....|.|::||...::|:..:|:|:.
Zfish   386 KLVALLMLSFLGRRLTQGACLLVSASIIFANIFVPEDMQVTRTALAVLGKGFTSASFTCVYLFTG 450

  Fly   446 EQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPETLNKP 510
            |.:|||:|..|:|..|.::|:|.:.||.:.:|.:|...||.|:.|..::.|||::.|||||||.|
Zfish   451 ELYPTVIRQTGMGFVSTMSRIGSMAAPAVLILDDILPALPSIVYGGSAVIAGLIAFLLPETLNIP 515

  Fly   511 MPETIEDGE-------NFGKKPAPQETAEEGGTQE 538
            :|:||:|.|       |..:..|.|:..:.||..|
Zfish   516 LPDTIDDVEEKWEKKNNTAEDLALQDVKQVGGAHE 550

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	177/512 (35%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	129/355 (36%)
oatx	XP_017208528.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	7.050