DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and SLC22A15

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_060890.2	Gene:	SLC22A15 / 55356	HGNCID:	20301	Length:	547	Species:	Homo sapiens

Alignment Length:	532	Identity:	180/532 - (33%)
Similarity:	273/532 - (51%)	Gaps:	52/532 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPHL 65
            |..::....:||.|.||   .||..|.|::...:......|:|...   |.|..:..:.||.|:.
Human     1 MEVEEAFQAVGEMGIYQ---MYLCFLLAVLLQLYVATEAILIALVG---ATPSYHWDLAELLPNQ 59

  Fly    66 WNLSYPENERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCSRSLLS 130
            .:.:....|..::.|...|   .|||         ....:|:..|.: .|..:||.|:.:||...
Human    60 SHGNQSAGEDQAFGDWLLT---ANGS---------EIHKHVHFSSSF-TSIASEWFLIANRSYKV 111

  Fly   131 ATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGATT 195
            :.:.|.|..||.:|.:.|||:||:.|||..:.....|.::|.:....:|.|..:.::|.:||...
Human   112 SAASSFFFSGVFVGVISFGQLSDRFGRKKVYLTGFALDILFAIANGFSPSYEFFAVTRFLVGMMN 176

  Fly   196 SGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFLCY 260
            .|:.|||:|:..|.||::|...||....:||:||....|...|||..||.|.|.:.|.|.:....
Human   177 GGMSLVAFVLLNECVGTAYWALAGSIGGLFFAVGIAQYALLGYFIRSWRTLAILVNLQGTVVFLL 241

  Fly   261 YWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPA--- 322
            ...||||.|||..:||..||...:...||.|                  :|.:...:.:.||
Human   242 SLFIPESPRWLYSQGRLSEAEEALYLIAKRN------------------RKLKCTFSLTHPANRS 288

  Fly   323 ----ATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTL 383
                .:..||.||..|...||::.|.|||.|.|||||:.:..:|||:...|..:||.:|||.|.|
Human   289 CRETGSFLDLFRYRVLLGHTLILMFIWFVCSLVYYGLTLSAGDLGGSIYANLALSGLIEIPSYPL 353

  Fly   384 LLFTLN-RW-GRRSILCGTMMVAGISLLATIFVPSDMNWLIVA------CAMIGKLAITSSYGTI 440
            .::.:| :| ||:..|...:.:.|::.|..:|:|...:..:.|      .:::|||.|::::..:
Human   354 CIYLINQKWFGRKRTLSAFLCLGGLACLIVMFLPEKKDTGVFAVVNSHSLSLLGKLTISAAFNIV 418

  Fly   441 YIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPE 505
            ||:::|.:|||:||||||..||.:|||||:||::..|..:...||.|:.||..||:|||||||||
Human   419 YIYTSELYPTVIRNVGLGTCSMFSRVGGIIAPFIPSLKYVQWSLPFIVFGATGLTSGLLSLLLPE 483

  Fly   506 TLNKPMPETIED 517
            |||.|:.||..|
Human   484 TLNSPLLETFSD 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	176/517 (34%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	129/370 (35%)
SLC22A15	NP_060890.2	MFS	111..469	CDD:119392	129/375 (34%)
		MFS_1	111..450	CDD:284993	123/356 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.850