DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Orct and SLC22A17

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_065105.3	Gene:	SLC22A17 / 51310	HGNCID:	23095	Length:	649	Species:	Homo sapiens

Alignment Length:	594	Identity:	157/594 - (26%)
Similarity:	250/594 - (42%)	Gaps:	105/594 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLCLPAIVCAFHKLAG-VFLLAKPDFRC---ALPYENGSIYEL 61
            :.::.::..:|..|..|:....|.|||.:..|....:. :|.|| |...|   |.| .|.|.:|.
Human    78 LSFEALLAQVGALGGGQQLQLGLCCLPVLFVALGMASDPIFTLA-PPLHCHYGAFP-PNASGWEQ 140

  Fly    62 SPHLWNLSY--------------------------PENERCSYYDVDYTEEYLNGSIPRSSNETK 100
            .|:...:|.                          |:...| ..|.||     ||....::|
Human   141 PPNASGVSVASAALAASAASRVATSTDPSCSGFAPPDFNHC-LKDWDY-----NGLPVLTTN--- 196

  Fly   101 TCSSYVYDRSKYLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASL 165
                           |:.:|:|||...........||:||...|.|..|..:|:.||:.....:|
Human   197 ---------------AIGQWDLVCDLGWQVILEQILFILGFASGYLFLGYPADRFGRRGIVLLTL 246

  Fly   166 VLQLIFGVLAAVAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGF 230
            .|....||..|.|.........|.::|...:||.|..|::.||:...:.||...:|.::....|.
Human   247 GLVGPCGVGGAAAGSSTGVMALRFLLGFLLAGVDLGVYLMRLELCDPTQRLRVALAGELVGVGGH 311

  Fly   231 MLTAGFAYFIHDWRWLQIAITLPGLLFLCYYW--IIPESARWLLMKGRKDEAFVIIEKAAKENKV 293
            .|..|.|....|||:||..||.|.:|||.|.|  :..||||||::|.:.:||..::...|:.|:.
Human   312 FLFLGLALVSKDWRFLQRMITAPCILFLFYGWPGLFLESARWLIVKRQIEEAQSVLRILAERNRP 376

  Fly   294 EVPNEIYEQLVDEVAEKKKQD-EMAASQPAATVF---DLLRYPNLRRKTLLIFFDWFVNSGVYYG 354
                  :.|::.|.|::..|| |.....||.:.|   .||.|.|:.:..|::.|..|:...:.:
Human   377 ------HGQMLGEEAQEALQDLENTCPLPATSSFSFASLLNYRNIWKNLLILGFTNFIAHAIRH- 434

  Fly   355 LSWNTNNLGGN----QLVNFMISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLA----- 410
             .:.....||:    .|.:.:.||...: ....|..|::|:|||.||..:|.:.||:.|.
Human   435 -CYQPVGGGGSPSDFYLCSLLASGTAAL-ACVFLGVTVDRFGRRGILLLSMTLTGIASLVLLGLW 497

  Fly   411 --------TIFVPS-----DMN-WLIVACAMIGKLAITSSYGTIYIFSAEQFPTVVRNVGLGASS 461
                    |::...     |:| ..|...:::|..:..::.....:.:||..||.||..|||...
Human   498 DCEHPIFPTVWAQQGNPNRDLNEAAITTFSVLGLFSSQAAAILSTLLAAEVIPTTVRGRGLGLIM 562

  Fly   462 MVARVGGILAPYLKL---LGEIWRPLPLIICGALSLTAGLLSLLLPETLNKPMPETIEDGE---- 519
            .:..:||:..|..:|   .|...:.:.|..|..|.:   |..:|||||..|.:||.:.|||
Human   563 ALGALGGLSGPAQRLHMGHGAFLQHVVLAACALLCI---LSIMLLPETKRKLLPEVLRDGELCRR 624

  Fly   520 -NFGKKPAP 527
             :..::|.|
Human   625 PSLLRQPPP 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	151/564 (27%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	109/387 (28%)
SLC22A17	NP_065105.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153303
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.940