DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and slc22a15.1

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_031751719.1	Gene:	slc22a15.1 / 448510	XenbaseID:	XB-GENE-959503	Length:	560	Species:	Xenopus tropicalis

Alignment Length:	568	Identity:	189/568 - (33%)
Similarity:	281/568 - (49%)	Gaps:	73/568 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQKRIYYLLC-LPAIVCAFHKLAGVFLLAKPDFRCALPYENGSIYELSPH 64
            |..:..:..:||.|.||..:.:||. |..:..|...:....|.|.|      ||          |
Frog    27 MEVEGALKLVGEMGIYQIYLSFLLAVLLQLYSATEAIIITILGATP------PY----------H 75

  Fly    65 LWNLSYPEN-ERCSYYDVDYTEEYLNGSIPRSSNETKTCSSYVYDRSKYLNSAVTEWNLVCSRSL 128
            ..|.|...| .|...|......|..:|.:....|.|               |.|:||.||...:.
Frog    76 WMNDSLTANGSRGKQYGSQLPAEGEHGHVVFDGNFT---------------SIVSEWFLVGGAAY 125

  Fly   129 LSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAAVAPEYFSYTISRMIVGA 193
            ..:.|.|::..|||:|.:.|||:||:.||||.:...|.|:::|.|:.|:.|.:..:.::|.:||.
Frog   126 EVSVSSSVYFGGVLIGVISFGQLSDRFGRKPVYVTGLALEVVFAVMNALTPIFPLFLLTRFLVGV 190

  Fly   194 TTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIHDWRWLQIAITLPGLLFL 258
            ...|:.|||:|:..|.:|:||...||....:.|:||....|...|||..||.|.:.:.:.|...|
Frog   191 MNGGMSLVAFVLLNECIGASYWAAAGSLGSLCFAVGIAQFALIGYFIRSWRLLALLVNVQGAAVL 255

  Fly   259 CYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDEVAEKKKQDEMAASQPAA 323
            .....||||.|||..:||..||...:....:.|:         :.|.......:|.:.|.|....
Frog   256 ALSLCIPESPRWLHAQGRLREAQESLLSLGRRNR---------RKVTSFTLCPRQKDSAHSANIL 311

  Fly   324 TVFDLLRYPN--LRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFMISGAVEIPGYTLLLF 386
            |:     |.|  ||::||::.:.|||.|.|||||:.::.:|||:..:|..:||..|:|.|.|.::
Frog   312 TI-----YSNAILRQRTLIMMWVWFVCSLVYYGLTLSSGDLGGDIYLNLALSGLAELPAYPLCMY 371

  Fly   387 TLN--RWGRRSILCGTMMVAGISLLATIFVP--------SDMNWLIVACAMIGKLAITSSYGTIY 441
            .:|  |.|||..|.|.:.|.|.:.|..:.||        |.:|  ....:::|||.|::::..:|
Frog   372 LINHKRVGRRGSLAGFLCVGGGACLLIMLVPGKTGSGPLSVLN--SQTLSLLGKLNISAAFNIVY 434

  Fly   442 IFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAGLLSLLLPET 506
            |:|:|.:||.|||:|:|..||.:|:|||:||::..|......||.|:.||..::|||||||||||
Frog   435 IYSSELYPTCVRNLGMGVCSMFSRIGGIIAPFIPALRFAHWALPFIVFGAAGVSAGLLSLLLPET 499

  Fly   507 LNKPMPETIEDGENFGKKPAPQETAEEGG-------TQELSGMLNGKS 547
            |:.|:|||:.|     .:.||....|..|       ..||....||.|
Frog   500 LSAPLPETLAD-----LRGAPYRRLEPDGEAMLHRPQAELGAFTNGSS 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	176/516 (34%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	129/367 (35%)
slc22a15.1	XP_031751719.1	MFS	90..497	CDD:421695	150/437 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D386678at33208
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920