DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Orct and Slc22a28

DIOPT Version :9

Sequence 1:	NP_001262908.1	Gene:	Orct / 42891	FlyBaseID:	FBgn0019952	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001013842.2	Gene:	Slc22a28 / 434674	MGIID:	3645714	Length:	552	Species:	Mus musculus

Alignment Length:	554	Identity:	160/554 - (28%)
Similarity:	263/554 - (47%)	Gaps:	36/554 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGYDDVITHLGEFGPYQ-KRIYYLLCLPAIVCAFHKLAGVFLLAKPDFRCALPY-------ENGS 57
            |.:.:::..:|..|.:| .:|.::|.|..:|.. |.....|..|.|:.||..|.       :|||
Mouse     1 MAFQELLNQVGSLGRFQILQISFVLFLVGLVVP-HITMENFTAAIPNHRCWAPILDNDTASDNGS 64

  Fly    58 IYELSPHLWNLSYPEN-----ERC-SYYDVDYTEEYLNGSIPRSSNE----TKTC-SSYVYDRSK 111
            .......|..:|.|.:     ::| .:....:...:|||:.   |||    |:.| ..:|||||.
Mouse    65 RILSQDDLLRISIPLDSNLRLDKCRRFAQPQWHLLHLNGTF---SNETEPDTEPCVDGWVYDRSN 126

  Fly   112 YLNSAVTEWNLVCSRSLLSATSDSLFMLGVLLGSLIFGQMSDKLGRKPTFFASLVLQLIFGVLAA 176
            :|::.||||:|||....|::.:...||:|:.:|::|.|.:||:.|||.....:|:...|.....|
Mouse   127 FLSTIVTEWDLVCESQALNSVAKFSFMIGLFIGAIICGHLSDRFGRKFILTCALLQFAITETCVA 191

  Fly   177 VAPEYFSYTISRMIVGATTSGVFLVAYVIALEMVGSSYRLFAGVAMQMFFSVGFMLTAGFAYFIH 241
            .||.:|.|.:.|.:.|.:...:.:.:.::.||.....:.....|......|:|:|:.||.|:...
Mouse   192 FAPSFFIYCLLRFLAGMSVEPISVNSNLLILEWTNPKFLGMVAVLTSCAASIGYMILAGLAFLFR 256

  Fly   242 DWRWLQIAITLPGLLFLCYYWIIPESARWLLMKGRKDEAFVIIEKAAKENKVEVPNEIYEQLVDE 306
            .|..||:|:::|...|......:.||||||::..:..:....:.|.|..|.::...   ..|..|
Mouse   257 IWHHLQLAMSVPIFFFFILTRWMSESARWLIVTNKPQKGLKELRKVAHMNGMKNSG---NTLTME 318

  Fly   307 VAEKKKQDEMAASQPAATVFDLLRYPNLRRKTLLIFFDWFVNSGVYYGLSWNTNNLGGNQLVNFM 371
            |.|...::|:.|::..::..||...|.||.:..::.|..::.:...:|||.:..:|..|.::...
Mouse   319 VVEASMKNELEAAKRKSSPRDLFHTPILRNRICVLSFMRYLFTVSIFGLSLHLQHLSTNIILLRF 383

  Fly   372 ISGAVEIPGYTLLLFTLNRWGRRSILCGTMMVAGISLLATIFVPSDMNWL----IVACAMIGKLA 432
            :|.|:.|....:..|.||..|||......|.:.||.:|..:|||.:|..|    :...|.:..|.
Mouse   384 LSSALGILISVIGHFVLNHMGRRITQLVLMSLRGIFMLTAVFVPQEMQTLRIIVVTLAAALSSLC 448

  Fly   433 ITSSYGTIYIFSAEQFPTVVRNVGLGASSMVARVGGILAPYLKLLGEIWRPLPLIICGALSLTAG 497
            :..|  .::|  .|..||.:|..|:|...|....|..|||...||......||.|..|..|:..|
Mouse   449 MCVS--NLHI--NELLPTTLRATGMGVIGMFGNSGLFLAPLFMLLATYSANLPWIFYGGFSILYG 509

  Fly   498 LLSLLLPETLNKPMPETIEDGENFGK--KPAPQE 529
            ....|||||.|:|:|::|.|..|..|  :.|.:|
Mouse   510 FSVFLLPETKNQPLPDSIHDVGNDWKDSRQAKEE 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Orct	NP_001262908.1	2A0119	11..514	CDD:273328	153/525 (29%)
Orct	NP_001262908.1	MFS	135..491	CDD:119392	99/359 (28%)
Slc22a28	NP_001013842.2	2A0119	11..525	CDD:273328	152/524 (29%)
Slc22a28	NP_001013842.2	MFS	151..516	CDD:119392	103/371 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167843649
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000012
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X24
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.940